Coeliac disease Flashcards

1
Q

what is the 1st line investigation for diagnosis of coeliac disease?

A

anti-tissue transglutaminase (TTG) antibody (IgG)

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2
Q

what are complications of coeliac disease?

A

malnutrition
anaemia: vitamin B12, folate, iron deficiency
osteoporosis
hyposplenism
lactose intolerence
enteropathy-associated T cell lymphoma of small intestine
oesophageal, colon cancer

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3
Q

what are histological features of a duodenal biopsy in coeliac disease?

A

subtotal/partial villous atrophy
crypt hyperplasia
increase intraepithelial lymphocytes
lamina propria infiltration with lymphocytes

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4
Q

what are presenting features of coeliac disease?

A

usually presents < 3 years but can present later

chronic or intermittent diarrhoea
recurrent abdominal pain, cramping, distention
recurrent GI symptoms including nausea and vomiting
fatigue
failure to thrive

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5
Q

why do patients with coeliac disease receive vaccinations and which ones do they get?

A

annual influenza and 5 yearly pneumococcal

due to functional hyposplenism

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