Coeliac Disease Flashcards
What is coeliac disease?
AI condition where exposure to gluten causes an autoimmune inflammation of the small bowel
When does coeliac usually present?
Childhood, but can be any age
Which antibodies are involved in coeliac?
- Anti-tissue transglutaminase (Anti-TTG)
- Anti-endomysial (Anti-EMA)
How do the autoantibodies reflect the disease course in coeliac?
Rise and fall with disease activity (will be low if the treatment is working)
Where in the small bowel does coeliac disease affect?
Jejunum
What does the autoimmune attack in coeliac disease cause?
Intestinal villi atrophy
What does intestinal villi atrophy cause in coeliac?
Malabsorption and malnutrition
How does coeliac disease present?
- Failure to thrive
- Weight loss
- Mouth ulcers
- Anaemia
- Dermatitis herpetiformis
What causes the anaemia in coeliac?
- Iron, B12 or folate deficiency
What type of anaemia is caused by iron deficiency?
Microcytic
What type of anaemia is caused by B12/folate deficiency?
Macrocytic
What is dermatitis herpetiformis?
Itchy, blistering rash often found on the abdomen
What conditions are linked to coeliac?
T1 DM
Thyoroid disease
PBC and PSC
What should you always do with a new T1 DM diagnosis?
Coeliac screen, even if no symptoms
What genetic associations are there in coeliac?
HLA-DQ2 (most)
HLA-DQ8
