coccidia 1 Flashcards

cryptosporidium

1
Q

Coccidia belong to which phylum?

A

apicomplexia

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2
Q

what are coccidia types ?

A

intestinal coccidia - blood and tissue coccidia

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3
Q

give what parasites are belong to the intestinal coccidia

A

cryptosporidium
isospora
cyclospora

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4
Q

give some parasites that belong to the blood & tissue coccidia

A

plasmodium
toxoplasm
babesia
sarcosystis

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5
Q

what are the general/in common characteristics of the intestinal coccidia parasites?

A

1-opportunistic in immunocompromized people
2-life cycle in one host
3-live in intestinal epithelial cells of the host
4-thick walled oocyst in feces
5-fecal-oral route transmission

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6
Q

what cryptospordium can cause(symptom)

A
  • self limiting diarrhia in healthy individuals
  • chronic persistent life threatening diarrhia in HIV individuals
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7
Q

C. parvum infect only humans?

A

no wide range of animals ( fish -humans)

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8
Q

which C. infect animals besides humans?

A

C.parvum

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8
Q

what C. infect only humans ?

A

C.hominis

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9
Q

what are other species of cryptospordium you know?

A

C. felis-canis-muris-meleagridis can also be found

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10
Q

how many hosts for C. parvum ?

A

one host animal or human

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10
Q

what is the morphology of c.parvum?

A

oocyts

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11
Q

what is the protection form of c. parvum?

A

sporulated oocytes -infective stage

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11
Q

what is the active form of c.parvum?

A

sporozoits

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12
Q

what is self limiting dirria?

A

means restricted frequently without drugs

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13
Q

what are the types of sporozoits based on location?

A

inside/outside sporocyst

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14
Q

what is the sexual form in c.barvum life cycle ?

A

meront ll

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14
Q

which type of sporozoit does C.barvum have?

A

it doesnt have sporocyst in first place

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15
Q

what is the asexual form of C.barvum?

A

meront l

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16
Q

what is excystation?

A

come out of the inside of the cyst

17
Q

what virulance means?

A

when enzymes balance change it become more valunarble to get c. as in AIDS

18
Q

what is the dignosis form of C.

A

oocyte found in feces

19
Q

what is the structure of oocyst in cryptosporidium?

A

cell wall and 4 sporozoites inside with no sporocyst

20
Q

what is the structure of sporozoites?

A

crescentic structure-pointed anterior end - blunt posterior end with nucleus

21
Q

what are the types of oocytes?

A

thick walled /thin walled

22
Q

explain the structure of thick wall oocyte?

A

2 electrodense walls
outer wall is thick and coarse
inner wall is granular and has suture at one pole
between them is electroluscent middle zone

23
Q

thin wall oocyte structure?

A

has only sinle wall

24
Q

oocyt walls are so resistant .what some disinfectants they might be resistant to?

A

chlorination -heat and dont stain by iodine and are fast stain in nature

25
Q

name th parasite in each stage of its life cycle in C.

A

1-sporulated oocyst(infective stage)
2-sporozoite(by excystation after ingesting it will invade the intestinal epithelial cells of the host)
sprozoites differentiate into trophozoites

3-trophozoite(feeding and growing stage its when the parasite forms)
inside trophzoites reproduction happens
meront l = asexual = 8 merozoites(infect other cells )
*outside trophozoite = meront ll = sexual (merozoites will be undifferentiated gametes then differentiate into macro and microgametes and fuse to form zygote)

4- zygote will be thick or thinn wall oocyst
thick =exit the host
thin = repeat the cycle inside the host

26
Q

what is the last role in C. thin wall oocyst life cycle ?

A

causes autoinfection through contaminated fingers

26
Q

what is the last role of C. thick walled oocyst?

A

excreted in feces and infect other people through feces

27
Q

what is the mode of transmissiom of C.?

A

Feco-oral route - ingestion of thick wall oocyst

28
Q

how the excystation of C. sporozoites start?

A

suture on the inner wall of oocyst dissolve and release 4 sporozoites into the intestines

29
Q

what factors might help in the excystation of the C. sporozoites?

A

bile salts like pancreatic enzymes

30
Q

where all the stages of C. development in human occur?

A

parasitophorous vacuole on brush border epithelium of the small intestines

31
Q

after excystation where C. sporozoites will stay/invade ?

A

on brush border epithelium inside parasitophorous vacuole ion the small intestines

32
Q

C. how meront l is formed?

A

from the first asexual /schizogony reproduction of trophozoites

33
Q

what the first thing happen to C. sporozoites after reaching the small intestines ?

A

differentiate into trophozoites to form meront l

34
Q

what C. meront l will produce asexually /schizogeny ?

A

8 merozoites then meront ll

35
Q

after C. gamtogony what we have ?

A

each microgamete give 16 microgametes
each macrogamete give 1 macrogamete

36
Q

whats the next step for zygote of C. ?

A

80% will be thick wall oocyst
20 % will be thin wall oocyst

37
Q

how long does the C. life cycle inside the human takes?/prepatent period

A

4-22 days

38
Q

LIST STAGES OF SPOROZOITES DEVELOPMENT INSIDE HUMAN

A

1-excystation
2-invasion
3-schizogony/asexual(3stages)
4-gamatogony/excystation
5-sporogony/zygote formation
6- final excystation

39
Q

what are virulence factors of C.?

A

1-membrane aminopeptidase
2-cysteine proteas
3-a heamolysin
4-lectin/thromboplastin related adhestion molecule

40
Q

clinical manefestation of C.?

A

1- self-limiting dirrhoeal illness(in immuncompetent person mostly children)
2-sever prolonged life threatening dirrhoeal( AIDS)

41
Q

what is the clinical manifestation for AIDS person in C. ?

A

intestinal =same symptoms and might led to death
extraintestinal=
-respiratory problems
-hepatitis
-pancreatitis
-cholecystitis

42
Q

which people C. mostly infect?

A

children and AIDS person

43
Q

prevention of C.

A

-water filteration -swimming pools-pasteurization - washing hands