Coated Vesicles in Cellular Transport Processes

Question 1

What are clatherin-coated vesicles surrounded by?

Answer 1

coats made of two multimeric proteins, clatherin and adaptor protein

Question 2

what do the shape and assembly of clatherin proteins do?

Answer 2

induce a flat membrane to form a spherical vesicle

Question 3

What is a Triskelion?

Answer 3

three legged structure, the basic unit of clatherin lattices

Question 4

each triskelion is a multimeric protein composed of:

Answer 4

• three large polypeptides (heavy chains) radiating from the central vertex
• three small polypeptides (lighter chains) close to vertex on inner leg

Question 5

what do triskelions assemble into? what does this form?

Answer 5

assemble into hexagons and pentagons, form lattice around clatherin-coated pits and vesicles

Question 6

what do adaptor proteins do?

Answer 6

promote assembly of clatherin coats

Question 7

how many type of adaptor protein complexes are there? and what are they composed of?

Answer 7

• 4 types

- each composed of 4 polypeptides ( 2 adaptin subunits, 1 medium chain, 1 small chain

Question 8

the _1.__ polypeptides, which are slightly different in each type of adaptor protein complex, bind to…?

Answer 8

1. 4

2. bind to different receptor proteins