Coagulation

Question 1

The time required for blood to form a clot?

Answer 1

Coagulation Time

Question 2

What pathways are evaluated in Prothrombin Time (PT)?

Answer 2

Extrinsic and Common pathways.

Question 3

What coagulation factors are associated with PT?

Answer 3

Factors 1, 2, 5, 7, and 10.

Question 4

What conditions are associated with prolonged PT?

Answer 4

Warfarin use, Vitamin K deficiency, and Liver disease.

Question 5

What pathways are detected by Activated Partial Thromboplastin Time (APTT)?

Answer 5

Intrinsic and Common pathways.

Question 6

What coagulation factors are associated with APTT?

Answer 6

Factors 1, 2, 5, 8, 9, 10, 11, and 12.

Question 7

What conditions are associated with prolonged APTT?

Answer 7

Heparin therapy and Hemophilia.

Question 8

What is assessed in Thrombin Time (TT)?

Answer 8

Fibrinogen function.

Question 9

What conditions are associated with abnormal TT?

Answer 9

Disseminated Intravascular Coagulation (DIC) and Dysfibrinogenemia.

Question 10

What is the function of Factor XIII in coagulation?

Answer 10

It is not associated with bleeding; its function is still unclear.

Question 11

What are the Vitamin K-dependent coagulation factors?

Answer 11

“1972” or 10, 9, 7, and 2.

Question 12

What factors are deficient in different types of Hemophilia?

Answer 12

Hemophilia A (F8)
Hemophilia B (F9)
Hemophilia C (F11)

Question 13

Which coagulation factor is associated with the Jewish population?

Answer 13

Factor 11

Question 14

What is the reference range for coagulation time?

Answer 14

2–4 minutes.

Question 15

What is the first step in the coagulation time procedure?

Answer 15

Disinfect the puncture site with 70% alcohol.

Question 16

Why should the puncture site be allowed to dry spontaneously?

Answer 16

To prevent alcohol interference with blood clotting.

Question 17

How deep should the lancet stab be for coagulation time testing?

Answer 17

3 mm deep.

Question 18

What should be done with the first drop of blood?

Answer 18

Wipe it off with dry cotton.

Question 19

When should the timer be started during coagulation test?

Answer 19

When the second drop of blood appears.

Question 20

How should the blood drop be collected in coagulation test?

Answer 20

On a clean slide without touching the wound or applying pressure.

Question 21

What is done every 30 seconds after starting the timer in coagulation test?

Answer 21

Run the lancet blade point across the blood drop and check for clot formation.

Question 22

When should the coagulation time be recorded?

Answer 22

When a string of blood clot is observed.

Question 23

What is the reference range for coagulation time using the Capillary Tube Method?

Answer 23

4–5 minutes.

Question 24

(Capillary Tube Method) How should the blood be collected for this test?

Answer 24

Fill the entire length of the capillary tube with the second drop of blood.

Question 25

(Capillary Tube Method) How is clot formation checked?

Answer 25

After 30 seconds, break a short piece of the capillary tube and check for a blood clot strand.

Question 26

(Capillary Tube Method) What should be done if no clot is seen?

Answer 26

Repeat breaking a piece of the capillary tube every 30 seconds until a clot strand is observed.

Question 27

(Capillary Tube Method) When should the coagulation time be recorded?

Answer 27

When a strand of blood clot is first observed.

Question 28

(Modified Lee and White Method) What is the reference range for coagulation time using this method?

Answer 28

7–15 minutes.

Question 29

(Modified Lee and White Method) When should the timer start?

Answer 29

As soon as blood appears at the hub of the syringe during venipuncture.

Question 30

(Modified Lee and White Method) How much blood is collected and how is it distributed?

Answer 30

4.5 mL of blood is collected and 1.5 mL is placed in each of the three test tubes.

Question 31

(Modified Lee and White Method) How long should the test tubes stand undisturbed before tilting?

Answer 31

5 minutes.

Question 32

(Modified Lee and White Method) How is clot formation checked in tube #3?

Answer 32

Tilt tube #3 at a 45° angle every 30 seconds until the blood no longer moves.

Question 33

(Modified Lee and White Method) What is done after tube #3 clots?

Answer 33

Repeat the tilting process for tube #2 and then tube #1, recording the end-point time.

Question 34

(Modified Lee and White Method) Which tube’s clotting time is reported?

Answer 34

Tube #1.