Coagulation Flashcards
List naturally occurring thrombophilias.
ATIII deficiency
Protein C deficiency
Protein S deficiency
Factov V Leiden
Prothrombin mutation G20210A
hyperhomocyteniemia
What are the most congenital thrombophilias?
Protein S deficiency
Factov V Leiden
Prothrombin mutation G20210A
hyperhomocyteniemia
What are acquired thrombophilias?
antiphospholipid antibody syndrome
cancer
pregnancy
OCP
HIT
What are the types of ATIII deficiency?
Type I decrease ATIII functional activity and antigen
Type II reduce ATIII functional activity and normal antigens
Type III moderate decrease activity due to impaired interaction with heparin
What is treatment for ATIII deficiency?
ATIII concentrates
Anticoagulation
FFP
What are the most common mutation for people with VTE?
Factor V leiden
Prothrombin mutation G20210A
What are the most common mutation for people with VTE?
Factor V leiden
Prothrombin mutation G20210A
What is HIT?
immune disorder
antibody response against antigens on pot factor 4
IgG antibodies directs against heparin-PF4 complex
What is the management of HIT?
stop heparin
alternate anticoagulant (argatroban
no plt trnasfusion
warfarin when pot normalize
What are heparin side effects?
bleeding
thrombocytopenia
osteoporosis
elevated transaminases
What are heparin side effects?
bleeding
thrombocytopenia
osteoporosis
elevated transaminases
What are absolute CI to thromblysis?
active bleeding
CVA, trauma, intraspinal/cranial surgery within 2 months
known intracrainal neoplasm
severe uncontrolled hypertension
uncontrollable clotting disorder
allergy
What are causes of DIC?
sepsis
major tissue injury
malignancy
How does uraemia lead to coagulopathy?
intrinsic plt defects
alteration of plt-endothelial interaction
List different hemostatic agents used in the OR.
gelatin (gelfoam)
oxidized cellulose (surgicel)
microfibrillar collagen (avitene)
polysaccharide spheres (arista)
fibrin sealants (tisseel)
thrombin sealant (floseal)
bovine-derived factors (bioglue gluteraldehyde crosslinked to albumin)
