Coagulation Flashcards

1
Q

List naturally occurring thrombophilias.

A

ATIII deficiency
Protein C deficiency
Protein S deficiency
Factov V Leiden
Prothrombin mutation G20210A
hyperhomocyteniemia

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2
Q

What are the most congenital thrombophilias?

A

Protein S deficiency
Factov V Leiden
Prothrombin mutation G20210A
hyperhomocyteniemia

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3
Q

What are acquired thrombophilias?

A

antiphospholipid antibody syndrome
cancer
pregnancy
OCP
HIT

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4
Q

What are the types of ATIII deficiency?

A

Type I decrease ATIII functional activity and antigen
Type II reduce ATIII functional activity and normal antigens
Type III moderate decrease activity due to impaired interaction with heparin

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5
Q

What is treatment for ATIII deficiency?

A

ATIII concentrates
Anticoagulation
FFP

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6
Q

What are the most common mutation for people with VTE?

A

Factor V leiden
Prothrombin mutation G20210A

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7
Q

What are the most common mutation for people with VTE?

A

Factor V leiden
Prothrombin mutation G20210A

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8
Q

What is HIT?

A

immune disorder
antibody response against antigens on pot factor 4
IgG antibodies directs against heparin-PF4 complex

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9
Q

What is the management of HIT?

A

stop heparin
alternate anticoagulant (argatroban
no plt trnasfusion
warfarin when pot normalize

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10
Q

What are heparin side effects?

A

bleeding
thrombocytopenia
osteoporosis
elevated transaminases

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11
Q

What are heparin side effects?

A

bleeding
thrombocytopenia
osteoporosis
elevated transaminases

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12
Q

What are absolute CI to thromblysis?

A

active bleeding
CVA, trauma, intraspinal/cranial surgery within 2 months
known intracrainal neoplasm
severe uncontrolled hypertension
uncontrollable clotting disorder
allergy

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13
Q

What are causes of DIC?

A

sepsis
major tissue injury
malignancy

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14
Q

How does uraemia lead to coagulopathy?

A

intrinsic plt defects
alteration of plt-endothelial interaction

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15
Q

List different hemostatic agents used in the OR.

A

gelatin (gelfoam)
oxidized cellulose (surgicel)
microfibrillar collagen (avitene)
polysaccharide spheres (arista)
fibrin sealants (tisseel)
thrombin sealant (floseal)
bovine-derived factors (bioglue gluteraldehyde crosslinked to albumin)

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16
Q

List different hemostatic agents used in the OR.

A

gelatin (gelfoam)
oxidized cellulose (surgicel)
microfibrillar collagen (avitene)
polysaccharide spheres (arista)
fibrin sealants (tisseel)
thrombin sealant (floseal)
bovine-derived factors (bioglue gluteraldehyde crosslinked to albumin)

17
Q

What are mediators of thrombogenicity in cancer?

A

Firbinogen,
factov VIII
plt count
Tissue factor
Vegf
PAR-2