Coagulation

Question 1

Chronic Nosebleeds (epistaxis) or bleeding with tooth extraction or surgery

Answer 1

Von Willebrands Disease

Question 2

Negative Ristocetin Test

Answer 2

Von Willebrands Disease

Question 3

Prolonged PT and PTT, low fibrinogen, positive D-dimer, or positive FDP

Answer 3

DIC (Disseminated Intravascular coagulation)

Question 4

Prolonged PT, normal PTT

Answer 4

Liver disease, Coumadin therapy, factor deficiency (factor VII or V, maybe X)

Question 5

normal PT, prolonged PTT, corrected with mixing studies

Answer 5

Factor deficiency (VIII, IX, X, XI, or fibrinogen)

Question 6

Prolonged thrombin time

Answer 6

Afibrinogenemia or dysfibrinogenemia or DIC

Question 7

Bleeding into joints (hemarthrosis)

Answer 7

Hemophilia (A or B)

Question 8

Petechiae, purpura, or eccyhymoses

Answer 8

low PLTs or abnormal PLTs

Question 9

Bleeding from gums

Answer 9

low PLTs

Question 10

Primary hemostasis

Answer 10

PLTs

Question 11

Secondary hemostasis

Answer 11

Coagulation cascade

Question 12

Prolonged PT

Answer 12

Factors V, VII, or X, fibrinogen or prothrombin (II), or Coumadin therapy

Question 13

Prolonged PTT

Answer 13

Factors VIII, IX, XI, X, or heparin therapy

Question 14

Prolonged bleeding time, normal PLT

Answer 14

Von Willebrands Disease

Question 15

Prolonged bleeding time, low PLT

Answer 15

Idiopathic thrombocytopenia purpura (ITP), TTP, or chemotherapy

Question 16

Prolonged PT, PTT, low fibrinogen

Answer 16

DIC

Question 17

Pos D-Dimer

Answer 17

DIC, deep vein thrombosis, pulmonary embolism

Question 18

Mixing studies, PT or PTT not corrected

Answer 18

Lupus anticoagulant

Question 19

Mixing studies, PT or PTT corrected

Answer 19

Factor deficiency

Question 20

Russell viper venom

Answer 20

Lupus anticoagulant

Question 21

Mixing Study

Answer 21

investigates abnormal clotting time results
-distinguishes between factor deficiency and inhibitor
-mixes patient plasma with normal pooled plasma and measures time that was initially prolonged