Coag/Haem Flashcards
Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
2020 JV MEd Sci Kobayashi
MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC.
A genetic polymorphism in P2RY1 impacts response to clopidogrel in cats with hypertrophic cardiomyopathy
seminal list
2021
The association with the P2RY1:A236G variant and clopidogrel resistance remained significant after adjustment for multiple comparisons.
This study demonstrated that a genetic polymorphism in the P2RY1 gene altered response to clopidogrel therapy and suggests that clinicians may consider alternative or additional thromboprophylactic therapy in cats with the P2RY1:A236G variant.
Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial JVIM Googs at al 2020
LP product appears to be logistically superior and is clinically non-inferior to DMSO-stabilized canine Cryopreserved platelet preparation for management of bleeding in thrombocytopenic dogs.
Stability of ex vivo coagulation factor activity in never-frozen and thawed refrigerated canine plasma stored for 42 days - JVECC Chee 2021
Refrigerated canine plasma from these 10 dogs retained coagulation factor activity above the limit that we defined as suitable for transfusion for up to 32 days when NEVER-FROZEN and 28 days when THAWED.
The role of cryoprecipitate in human and canine transfusion medicine
Review JVECC 2021
Low fibrinogen in dogs (as in people) has been documented with acute traumatic coagulopathy, advanced liver disease, and disseminated intravascular coagulation. Bleeding secondary to these hypocoagulable states may be amenable to cryoprecipitate therapy. Indications for preferential selection of cryoprecipitate (versus fresh frozen plasma) remain to be determined.
Xenotransfusion of canine blood to cats: a review of 49 cases and their outcome Le Gal (the queen G) 2022 JSAP
Xenotransfusion of canine packed red blood cells to cats is possible but haemolysis should be expected between 1 and 6 days after transfusion.
Randomized double-blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells JVIM 2021 Radulescu (the other queen)
A clinical advantage of using LR over N-LR PRBC in terms of Tranf Reactions and increase in PCV after transfusion was not detected.
Quantitative assessment of infusion pump-mediated haemolysis in feline packed red blood cell transfusions JFMS 2021 Blasi-Bruge
use of two common Peristaltic infusion Pumps in veterinary hospitals does not produce levels of haemolysis that are significantly different than that caused by gravity alone during transfusion of feline pRBCs at a rate of 25 ml/h.
The effect of time on packed cell volume following packed red blood cell transfusion in anemic dogs 2021 JVEC Morris
There was no significant change in PCV from the value obtained immediately after pRBC transfusion up to 4 hours post-transfusion in dogs with several different causes of anemia.
Indications for use and complications associated with canine plasma products in 170 patients Santo-Domingo JVECC 2021
Reactions were noted in 4%
Administration of canine plasma products appears to be a safe procedure that carries a low risk of transfusion reactions.
Type-matching of canine PP appears unnecessary and does not reduce the incidence of TR in dogs.
Reasons for transfusion: Oncotic support, sepsis, coagulopathy, internal bleeding, trauma, GDV, mucosal bleeding
Prospective evaluation of the utility of cross-matching prior to first transfusion in cats: 101 cases JSAP 2020
Humm and Chan
Transfusion reactions were fairly common but not associated with increased mortality. Use of crossmatch-compatible blood did not lead to a greater increase in PCV at 12 hours. The commercial test may predict a haemolytic transfusion reaction.
Exploration of risk factors for non-survival and for transfusion-associated complications in cats receiving red cell transfusions: 450 cases (2009 to 2017) JSAP 2020Martinez-Soagues
exploratory observational study
Suggest that major cross-match before transfusion tended to have greater transfusion efficacy and transfusion of older blood products might have detrimental effects on survival.
Left heart dimensions in anaemic cats and dogs before and after blood transfusion - JVIM 2021 Donaldson
Blood transfusion is well tolerated when signs of volume overload are present before transfusion.
In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques JVECC 2021
Despite a storage time of ≤14 days, 15% of pRBC units had unsuitable (>0.8%) hemolysis before even being subjected to the trials.
rapid infusion techniques in small animal transfusion medicine do not cause significant iatrogenic hemolysis of canine pRBCs in vitro, although a significant risk is present in stored blood.
Neutrophil extracellular traps in stored canine red blood cell units McQuinn JVIm 2020
Markers of NETs increased during RBC storage nd were higher in NLR than LR units. NETs might be mediators of transfusion reactions.
