co-ordinated communication in the immune system

Question 1

what do tissue resident cells secrete to attract other cells?

Answer 1

Chemokines which are cytokines

Question 2

chemokines control immune cell movment using receptors. what is function of dendritic cells expressing CCR7 induced by CCL21 chemokine

Answer 2

CCR7- immune cell migration of T cells and dendritic cell to secondary lymphoids
CCL21- ligand for CCR7

Question 3

what are cytokines and 3 things they include

Answer 3

small signalling proteins that regulate immune systum functions
1) interleukins
2) interferons
3) chemokines

Question 4

CD4 helper T cells also shape tissue response.
TH1 cells=
-cytokine production
-what do these cytokines activate
-cell mediated immunty against what pathogens

Answer 4

-produce IFN-y, IL-2 and TNF-a
-these cytokines activate macrophages and cytotoxic T cells. resulting in inflammation
-cell mediated immunity for intracellular pathogens

Question 5

how are TH2 cell specialied for helping clear multicellular pathogens
-cytokine production
-what these cytokines activate
-what these cytokines recruit
-humoural immunity against what pathogens

Answer 5

-IL-4, 5 and 13.
-these cytokines activate B cells (IgG antibody)
-it recruits eosinphils and mucous secretion. associated with allergies.
-humoural immunity from extracellular pathogens

Question 6

which organelle realses enzyme responsible for breaking down pathogens during phagocytosis by macrophages

Answer 6

lysosomes