CNS white matter and dz

Question 1

what stains like a fried egg

Answer 1

oligodendrocytes

Question 2

MS characterized

Answer 2

perivascular inflammatory cells, loss of oligodendrocytes

Question 3

what is PML caused by

Answer 3

JC strain of papovavirus - occurs in immunocompromised pts

Question 4

progression of PML

Answer 4

multiple foci of demyelination in subcortical white matter in early lesion

“rat bitten appearance to white matter of brain”

Question 5

PML

Answer 5

progressive multifocal leukoencephalopathy

Question 6

central pontine myelinolysis

Answer 6

caused by rapid correction of serum electrolyte imbalance

get demyelination in center of pontine base
decreased oligodendrocytes within demyelinating lesion

Question 7

aids leukoencephalopathy

Answer 7

diffuse pallor of cerebral white matter on myelin stain
perivascular presence of multinucleated giant cells
associated with AIDS dementia - loss of neurons

Question 8

leukodystrophy

Answer 8

caused by mutation of gene for myelin protein or specific enzyme for myelin lipid metabolism
very sick kids little cognition