CNS Viruses

Question 0

Flavaviridae viruses

Answer 0

West Nile Virus, St. Louis encephalitis virus, Japanese encephalitis virus.

Question 1

Flavavirus genome

Answer 1

Single stranded + sense RNA virus enveloped

Question 2

Togaviridae viruses

Answer 2

Western equine virus, eastern equine encephalitis, Venezuelan equine encephalitis

Question 3

Bunyaviruses

Answer 3

California encephalitis virus and La Crosse virus

Question 4

Togaviridae genome

Answer 4

Enveloped, non segmented; (+) sense RNA

Question 5

Bunyavirus genome

Answer 5

Enveloped, segmented, single stranded, negative sense RNA

Question 6

Rabies virus genome

Answer 6

Non-segmented negative sense RNA

Question 7

Glycoprotein for attachment to ACh receptors and fusion

Answer 7

Rabies

Question 8

Arenaviridae genome

Answer 8

Segmented, ambience RNA virus; enveloped

Question 9

Arenaviridae virus

Answer 9

Lymphocytic choriomeningitis virus

Question 10

2 phases of disease:
initial prodrome of fever, headache, and n/v
Aseptic meningitis 10 days later

Answer 10

Lymphocytic choriomeningitis virus

Question 12

Arenaviridae replication cycle

Answer 12

• NP and L proteins synthesized by viral polymerase upon endocytosis into cell
• NP and L proteins promote replication
• Synthesis of full length anti-genome RNA
• Anti genome used as a template for protein synthesis and glycoprotein translation (in opposite direction)
• Release via budding.

Question 13

characteristically affects the temporal lobe

Answer 13

HSV-1 encephalitis

Question 14

HSV pathogenesis

Answer 14

virus enters local sensory nerve endings and undergoes axonal transport proximally to sensory ganglion cell bodies; rarely may spread to the brain resulting in focal necroticc lesions in the temporal lobe leading to inflammation and encephalitis

Question 15

enteroviruses

Answer 15

echovirus, coxsackie virus, and enterovirus 71