CNS Tumors Pathology Flashcards
grading of pilocytic astrocytoma
WHO grade 1
where are pilocytic astrocytoma usually found
optic nerve, cerebellar hemisphere
cystic, solid, GFAP positive, rosenthal fibers
pilocytic tumor
mean survival of diffuse astrocytoma
6-8 years
diffuse astrocytoma WHO grade ?
WHO Grade II
gemistocytic, fibrillary, and r protoplastic
diffuse astrocytoma
where are diffuse astromctyomas found often
temporal lobes
which type of astrocytoma associated with seizures
diffuse astrocytoma
anaplastic astrocytoma
WHO Grade III
what is the mean survival of anaplastic astrocytoma
3 years
morphology of astrocytes
dense, nuclear atypia, proliferation
WHO grade IV
glioblastoma
what is the MOST frequent brain tumor
glioblastoma
hemispheric white matter, edema, necrosis, and widespread infiltration, nuclear pleomorphism, and pseudopalisades
glioblastoma
how does astrocytoma spred
subarachnoid (drop metsastasis)
higher grade astrocytoma
RB and P16/CDKnA
what is treatent for astrocytomas
radiation therapy and chemotherapy such as temozolamide
oligodendroglioma grade WHO
grade II
anaplastic oligodendroglioma grade
grade III
where are oligodendrogliomas ound
cerebral hemispheres
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halos around tumor nuclei
oligodendroglioma