CNS - Strategies on drug delivery

Question 1

Drugs must pass through the

Answer 1

lipophilic blood-brain barrier (BBB)before exerting an affect

Question 2

what are the lipophilic barriers?

Answer 2

intestinal membrane
BBB

Question 3

BBB excludes almost 100% of high MW drugs and______ of low MW drugs

Answer 3

> 98%

Question 4

What are the routes across the BBB?

Answer 4

• cell migration
• passive diffusion
• carrier mediated efflux
• carrier mediated influx
• receptor mediated transcytosis
• adsorptive mediated transcytosis
• TJ modulation

Question 5

what is the best way route to pass the BBB?

Answer 5

Intraspinal injections

Question 6

What is the brain and spinal cord is surrounded by…

Answer 6

cerebrospinal fluid (CSF)

Question 7

Challenges of the intraspinal route

Answer 7

Challenges of the intraspinal route

Question 8

Intrathecal delivery to the brain

Answer 8

avoid intrathecal injections subcutaneous implanted pumps
- implanted up to 7 years
- 1-6 months (refilled)

Question 9

Intranasal delivery to the brain: routes

Answer 9

Route 1: Olfactory nerve cells (neurons)

Route 2: Trigeminal nerve

Question 10

We need to find a polymer that will slowly degrade and release carmustine at the required site of action – which polymer?

Answer 10

Nylon is a polyamide – very stable

Question 11

Polyanhydrides also h________ quickly

Answer 11

hydrolise