CNS intro

Question 1

what is a synapse?

Answer 1

When one neurone meets another

Question 2

Ionotropic

Answer 2

ion channels that open in response to the binding of a neurotransmitter.

Question 3

GPCR

Answer 3

Neurotransmitters act as ligands for many G protein-coupled receptors (GPCRs) well known for modulating neural activity

Question 4

Ionotropic receptorsexcitatory synapses

Answer 4

Transmitter depolarizes and excites

Question 5

Ionotropic receptors - inhibitory synapses

Answer 5

Transmitter hyperpolarizes and inhibits
Inward negative current
Inhibitory postsynaptic potential (IPSP)

Question 6

GPCR - linked to what ion channels

Answer 6

K and Ca

Question 7

What enzymes are linked to GPCR

Answer 7

adenylyl cyclase
phospholipase C

Question 8

What are the key differences between brain and general capillaries?

Answer 8

General cap
- fenestrated or continuous
- small solutes diffuse through intercellular clefts
- pino cytosis of molecular size

Brain capillary
- continuous
- no fenestra
- tight functions
- reduced pinocytosis
-astrocyte foot processes