CNS Pharma Flashcards
What is increased in central sensitization?
Calcium
How does NAMDA receptor activation initiate central sensitization?
a. Increased intracellular calcium through activation of adenylate cyclase
b. decrease intracellular calcium through inhibition of adenylate cyclase
c. Increased calcium entry through linked receptors
d. decreased calcium entry through linked receptors
C
How does NMDA receptor activation initiate central sensation?
a. Increase intracellular Ca+ through activation of adenyl cyclase
b. Decrease intracellular Ca+ through inhibition of adenyl cyclase
c. Increase Ca+ entry through linked receptor
d. Decrease Ca+ entry through linked receptor
e. Increase Cl- entry through linked receptor
C
How does the NK-1 receptor participate in inducing central sensitization?
By increasing the release of calcium from intracellular stores by forming IP3
What is responsible for central sensitization of pain?
a. GABA
b. Glycine
c. NMDA and NK1
C
How does the NK-1 receptor participate in inducing central sensitization?
By increasing intracellular CA2+ release from stores by IP3
Which receptor is responsible for serotonin excitatory action?
a. 5-HT1 receptor
b. 5-HT2 receptor
c. 5-HT3 receptor
d. 5-HT4 receptor
C
What is the mechanism of action of neurokinin-1?
a. Increase Ca2+ release from intracellular stores via inositol trisphosphate
b. Increase intracellular Ca2+ through voltage-gated Ca2+ channels
A
What describes the mechanism through which long term depression occurs?
Phosphorylation and internalization of AMPA receptors
How does the NK-1 receptor work?
Increase the release of calcium from intracellular stores by increasing the synthesis of inositol
triphosphate (IP3)
Long Term Potentiation
↑ entry of Ca & insertion of AMPA
What is the consequence of NK-1 activation?
Intracellular Ca will increase by inositol triphosphate
Noxious receptors
Increase Ca influx
What receptor that once activated can also produce PG-I & PG E?
Bradykinin B2 receptor
What type of receptor does the muscle relaxant baclofen work on?
a. GABA-A receptor
b. GABA-B receptor
c. GABA-C receptor
d. NMDA receptor
e. Histamine H1 receptor
B
A patient recently diagnosed with MS has severe anxiety and can’t sleep. What drug can be used for her muscle cramps/ spasms?
a. Diazepam
b. Tiagabine
c. Valproate
A
A young woman with a long history of depression, accompanied by body aches and pain. Which drug is useful for her?
a. Diazepam
b. Tiagabine
c. Valproate
A
Which drug can be given to reduce anxiety and relieve muscle strain?
Diazepam
Which of the following increases dopamine and noradrenaline in the synaptic cleft?
a. Nicotine
b. Amphetamine
c. Cocaine
B
Mr.Ali has been addicted to a drug for a very long time. He ended up having cirrhosis and liver failure. Which of the following drugs of abuse he was addicted to?
a. Heroin
b. LSD
c. Cannabis
d. Ethanol
D
What is the mechanism of action of cannabinoids on CB1 receptor?
Inhibition of adenylate cyclase, decreasing the production of cAMP
Which drug inhibits the reuptake of noradrenaline, serotonin, and dopamine.
a. Caffeine
b. Nicotine
c. Cannabinoids
d. Cocaine
D
Which drug inhibits Phosphodiesterase?
a. Caffeine
b. Nicotine
c. Cannabinoids
d. Cocaine
A
What is the mechanism of action of Cannabis on the CB1 receptor?
Block AC, close Ca, open K
