CNS - peptides,proteins

Question 1

Mechanism and use of:

Aprotynine

Answer 1

inhibits serine proteases

Use: prevents hyperfibrinolytic bleeding

Question 2

Mechanism and use of:

Ecallantide

Answer 2

Kallikrein inhibitor
- Reduce bradykinin levels

Use:
-Heredetitary angioedema

Question 3

Mechanism and use of:

Icatibant

Answer 3

B2 bradykinin receptor blocker

Use:
-Hereditary angioedema

Question 4

Mechanism and use of:

Nesiritide

Answer 4

BNP receptor antagonist:

Use:
- Acute heart failure

Question 5

Mechanism and use of:
Bosentant
Macitentan
Ambrisentant

Answer 5

Endothelin receptor antagonists

Use:
- Pulmonary hypertension

Question 6

Mechanism and use of:

Aprepitant

Answer 6

Tachykinin NK1 receptor antagonist

Use:
Antiemetic after chemo

Question 7

Mechanism and use of:

Capsaicin

Answer 7

Releases substance P from nerve endings
(it is the ‘hot’ part of chilli pepper)

Use:
-Topical analgesic