CNS - antidepressants Flashcards
1
Q
Amitriptyiline
Clomipramine
Imipramine
- Mechanism?
- Uses? (3)
- Adverse effects?
A
TCAs:
- Blocks NE and 5-HT transporters
(also alpha and M block) - Major depression (backup)
chronic pain
OCD - (Clomipramine) - sedation, weight gain
overdose: arrythmias, seizures
CYP450 interactions
2
Q
Citalopram
Fluoxetine
Paroxetine
Sertraline
- Mechanism?
- Uses? (6)
- Adverse effects?
A
SSRIs:
- Blocks serotonin reuptake
2. Major depression Anxiety disorders OCD PMDD (pre - menstrual dysphoric disorder) PTSD bulimia
- Sexual dysfunction
CYP inhibitors!
3
Q
Venlafaxine
Desvenlafaxine
Duloxetine
- Mechanism?
- Uses? (4)
- Adverse effects?
A
SNRIs:
- Blocks NE and serotonin reuptake
- Major depression
Chronic pain
fibromyalgia
menopausal symptoms - Anticholinergic
Sedation
Hypertension (Venlafaxine)
4
Q
Nefazodone
Trazodone
- Mechanism?
- Uses? (2)
- Adverse effects?
A
- 5-HT2 antagonists
- Major depression
Hypnosis (Trazodone) - Sedation
alpha/H1 blockage (modest)
CYP inhibition (Nefazodone)
5
Q
Amoxapine
Bupropion
Maprotiline
Mirtazepine
- Mechanism?
- Uses? (3)
- Adverse effects?
A
- Mirtazepin blocks alpha2
Mechanism of others uncertain - Major depression
Smoking cessation (Bupropion)
Sedation (Mirtazepine) - sedation and weight gain (Mirtazepine)
Lower seizure threshold (amoxapine, bupropion)
CYP inhibition (bupropion)
6
Q
Isocarboxazid
Phenelezine
Selegine
- Mechanism?
- Use? (1)
- Adverse effects?
A
- Inhibits MAO A and B (Selegine - B)
- Major depression unresponsive to other drugs
- Hypertension (Tyramine/symptatethics)
Serotonin Syndrome (with SSRIs)
Hypotension
Insomnia