CNS - antidepressants Flashcards

1
Q

Amitriptyiline
Clomipramine
Imipramine

  1. Mechanism?
  2. Uses? (3)
  3. Adverse effects?
A

TCAs:

  1. Blocks NE and 5-HT transporters
    (also alpha and M block)
  2. Major depression (backup)
    chronic pain
    OCD - (Clomipramine)
  3. sedation, weight gain
    overdose: arrythmias, seizures

CYP450 interactions

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2
Q

Citalopram
Fluoxetine
Paroxetine
Sertraline

  1. Mechanism?
  2. Uses? (6)
  3. Adverse effects?
A

SSRIs:

  1. Blocks serotonin reuptake
2. Major depression
    Anxiety disorders
    OCD
    PMDD (pre - menstrual dysphoric disorder)
    PTSD
    bulimia
  1. Sexual dysfunction

CYP inhibitors!

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3
Q

Venlafaxine
Desvenlafaxine
Duloxetine

  1. Mechanism?
  2. Uses? (4)
  3. Adverse effects?
A

SNRIs:

  1. Blocks NE and serotonin reuptake
  2. Major depression
    Chronic pain
    fibromyalgia
    menopausal symptoms
  3. Anticholinergic
    Sedation
    Hypertension (Venlafaxine)
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4
Q

Nefazodone
Trazodone

  1. Mechanism?
  2. Uses? (2)
  3. Adverse effects?
A
  1. 5-HT2 antagonists
  2. Major depression
    Hypnosis (Trazodone)
  3. Sedation
    alpha/H1 blockage (modest)

CYP inhibition (Nefazodone)

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5
Q

Amoxapine
Bupropion
Maprotiline
Mirtazepine

  1. Mechanism?
  2. Uses? (3)
  3. Adverse effects?
A
  1. Mirtazepin blocks alpha2
    Mechanism of others uncertain
  2. Major depression
    Smoking cessation (Bupropion)
    Sedation (Mirtazepine)
  3. sedation and weight gain (Mirtazepine)
    Lower seizure threshold (amoxapine, bupropion)

CYP inhibition (bupropion)

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6
Q

Isocarboxazid
Phenelezine
Selegine

  1. Mechanism?
  2. Use? (1)
  3. Adverse effects?
A
  1. Inhibits MAO A and B (Selegine - B)
  2. Major depression unresponsive to other drugs
  3. Hypertension (Tyramine/symptatethics)
    Serotonin Syndrome (with SSRIs)
    Hypotension
    Insomnia
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