CNS path nichols Flashcards
10 steps of anoxic enchephalopathy
- After 3 minutes without blood supply,
neurons run out of energy (ATP).
Without energy, neurons leak potassium
and take in calcium.
- Excess intra-neuronal calcium injures mitochondria,
cytoskeletal proteins and protein synthesis; it also
activates proteases, lipases and nucleases. - As a result of calcium-mediated badness, neurons die.
- After 15 minutes of cardiac arrest,
up to 95% of the brain may be damaged. - Reperfusion of dead brain brings calcium and
oxygen (generating reactive oxygen species)
and causes edema through leaky blood vessels. - Brain edema causes cerebellar tonsillar herniation
into the foramen magnum. - Cerebellar tonsillar herniation compresses
the medulla. - Compression of the medullary respiratory center
causes cessation of breathing and death unless… - a patient is given ventilatory support,
which allows the compressed parts of the brain
to undergo necrosis.
Liquefactive
necrosis with
infiltration by
macrophages
containing
cell debris,
myelin and
a little
hemosiderin.
what is at:
- 12 hours
- 24-48 hours
- 72 hours-3 weeks
- 3 weeks- 3 months
Ridiculously oversimple timetable:
12 hours: red neurons.
24-48 hours: neutrophils.
72 hours-3 weeks: macrophages.
3 weeks-3 months: astrocyte proliferation around empty space,
with their processes forming wall around the hole left behind.
4 hydrocephalus causes in a baby?
Hydrocephalus: Causes:
In a baby
1) intraventricular
matrix hemorrhage
(premature infants)
2) Arnold-Chiari
malformation
3) Dandy-Walker
malformation
4) spina bifida
2 hydrocephalus causes in an older child?
In an older child:
tumor (ependymoma,
medulloblastoma)
2) infection
2 hydrocephalus causes in an adult?
In an adult:
1) subarachnoid
hemorrhage
2) tumor
(astrocytoma,
metastasis)
“bruise, an area of hemorrhage
into soft tissue due to rupture of blood vessels
caused by blunt trauma”
contusion
What is it?
“Herpes encephalitis starts in, and most
severely involves, the inferior and medial
regions of the temporal lobes and the orbital
gyri of the frontal lobes. The infection is
necrotizing and often hemorrhagic in the
most severely affected regions.”
Enlarged cells with
irregularly oval shaped
nuclei containing lilac
colored ground glass
intranuclear inclusions
and marginated native
chromatin, and necrosis
what is described?
Herpes simplex virus encephalitis
what are the 3Ms of Herpes?
Multinucleation, Molded nuclei and Marginated chromatin.
cells in brains only have one nucleus: exception: brain, liver, at times lung
what is upward gaze paresis?
the association?
Upward gaze paresis
associated with
high intracranial pressure
especially due to hydrocephalus
can be the earliest sign
________ gene amplification (not mutation) is a feature of neuroblastoma.
Neuroblastoma is a tumor of neural crest-derived cells that occurs outside
the brain in small children (median age 2 years old).
NMYC gene amplification (not mutation) is a feature of neuroblastoma.
Neuroblastoma is a tumor of neural crest-derived cells that occurs outside
the brain in small children (median age 2 years old).
________ mutation is associated with neurofibromas and germline NF1 mutation
is associated with type 1 neurofibromatosis.
NF1 mutation is associated with neurofibromas and germline NF1 mutation
is associated with type 1 neurofibromatosis.
Germline ________mutations are present in 25% of melanoma-prone kindreds.
Germline CDKN2A mutations are present in 25% of melanoma-prone kindreds.
Tumoral________ deletions or inactivations are seen in up to 70% of
glioblastomas.
Somatically acquired _______ deletions or inactivations are present in
many kinds of cancer.
Acquired _______ deletions or inactivations are present in 75% of
pancreatic carcinomas. If you have only enough spare memory for
one association of messed up CDKN2A, pancreatic carcinoma might
be the best one to remember.
Tumoral CDKN2A deletions or inactivations are seen in up to 70% of
glioblastomas.
Somatically acquired CDKN2A deletions or inactivations are present in
many kinds of cancer.
Acquired CDKN2A deletions or inactivations are present in 75% of
pancreatic carcinomas. If you have only enough spare memory for
one association of messed up CDKN2A, pancreatic carcinoma might
be the best one to remember.
what is the DDX for ring-enhancing lesions?
MAGIC DRL
M: Metastasis
A: Abscess
G: Glioblastoma multiforme
I: Infarct (subacute phase)
C: Contusion
D: Demyelinating disease
R: Radiation necrosis or
Resolving hematoma
L: Lymphoma
