anti malaria and anti-helminth Flashcards
chloroquine
low dose ADE(3)
high dose ADE(2)
which heart defects?
low dose- GI distress, rash, headache
high dose - auditory dysfunction and retinal dysfunction
Abnormal ECG; prolonged QT interval
mefloquine
ADE:
low dose
high dose
Low - GI distress, rash, headache
high - cardiac conduction, defects and neurlogic symptoms(highg dose)
quinine
ADE
Cinchonism, hemolysis in G6PD deficiecny, blackwater fever(intravascular hemolysis)
primaquine
main use and ADE(3)
eradication of liver stages of P vivax and P ovale
GI distress, methemoglobinenmia, hemolysis in G6PD
atovaquone- proguanil ADE
GI distress, headache, rash
artesunate, artemether
uses
1 ADE
tx of multi-drug resistan malaria
GI distress
3 symptoms of cinchonism
which drug?
GI distress, headache, vertigo, blurred vision, tinnitus
quinine
this tetracycline is chemoprophylactic for travelers to geographical areas with both chloroquine and melfoquine-resistant P falciparum
doxycycline
this quinone derivative is a component of malarone with progaunil, appears to disrupt mitochondrial electron transport in protozoa. malarone is effective for both chemoprophylaxis and tx of falciparaum malaria. abdominal pain and GI effects occur at the high doses used to tx.
atovaquone
why are artesunate and arthemether not used for chemoprophylaxis?
b/c of their short half-lives of 1-3 hours
what are the only drugs available that are reliably effective aginst quinine resistant malaria?
artesunate and artemether
is primaquine safe to use in pregnacy?
NO!!! contraindicated in pregnancy
