CNS Neurotransmitters

Question 1

Acetyl choline site and effect

Answer 1

1. Terminals of large pyramidal cells
2. Neurons in basal ganglia
3. Motor neurons innervating skeletal muscles
4. Preganglionic N. Of autonomic NS
5. Postganglionic N. Of parasympathetic NS
6. Some postganglionic N. Of sympathetic NS

Mostly excitatory.
Inhibitory at peripheral parasympathetic nerve ending like vagus nerve

Question 2

Norepinephrine site and effect

Answer 2

1. Locus ceruleus in pons (controls overall activity and mood of brain)
2. Most postganglionic N. Of sympathetic
3. N. With cell bodies in brain stem and hypothalamus

Both exc. and inhib.

Question 3

Dopamine site and effect

Answer 3

1. Neurons originating in substantia Niagra; terminating in striatal region of basal ganglia

Question 4

Dopamine site and effect

Answer 4

1. Neurons originating in substantia Niagra; terminating in striatal region of basal ganglia

Inhibitory

Question 5

Glycine site and effect

Answer 5

1. Synapses of spinal cord

Inhibitory

Question 6

GABA

Answer 6

1. Synapses of spinal cord, cerebellum, basal ganglia and other areas of cortex

Inhibitory

Question 7

Glutamate

Answer 7

1. Presynaptic terminals of sensory pathways entering CNS

Excitatory

Question 8

Serotonin site and effect

Answer 8

1. Nuclei originating from median raphe of brainstem; projecting to dorsal horns of spinal cord and hypothalamus

Inhibits pain pathways
Controls mood and sleep

Question 9

Nitric oxide site and effect

Answer 9

1. In areas for long term behavior and memory

Synthesized instantly and diffuses over seconds.
Alters intracellular metabolic functions.