CNS General Flashcards

1
Q

Input to hypothalamus

A
Amygdala
Hippocampus
Thalamus
Prefrontal cortex
Olfactory cortex
Tegmentum
Striatum
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2
Q

Output from hypothalamus

A
Tegmentum
Thalamus
ANS
Brainstem centres
Hypophysis
Subthalamic body
Reticular formation
Limbic system
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3
Q

Food intake hypothalamus

A

VMN(glucostats) - satiety centre - inhibits food intake
LN - Feeding centre - increases food intake

-increase in blood glucose activates VMN in post prandial state

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4
Q

Peptides influencing food intake

A

Increasing

  1. Neuropeptide Y - by arcuate nucleus
  2. Orexin A and B - by lateral hypothalamus
  3. Ghrelin - stomach and hypothalamus

Decreasing

  1. MSH
  2. CRH
  3. ACTH
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5
Q

Leptin

A
  • produced by adipose tissue
  • secretion proportional to size of fat depot
  • inhibits food intake
  • long term regulation
  • deficiency causes obesity
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6
Q

Gut peptide theory

A

CCK, glucagon, somatostatin, GRP secreted by gut inhibit food intake

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7
Q

Thermostatic theory of food regulation

A

Fall in core temp. Increases appetite and vice versa

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8
Q

Regulation of body temp by hypothalamus

A

Preoptic nuclei
Anterior hypothalamus
Posterior hypothalamus

  • preoptic nuclei have temperature sensors that detect through blood flowing through hyp., And by cutaneous receptors on cortex
  • anterior hyp regulates in hot environment
  • posterior hyp regulates in cold environment
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9
Q

Regulation of thirst by hypothalamus

A

Lateral hypothalamus
Preoptic area

  • increased tonicity simulates osmoreceptors
  • decreased ECF volume simulates baroreceptors and angiotensin ii
  • angiotensin ii acts on subfornical organ
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10
Q

Cardiovascular regulation of hypothalamus

A

Posterior and lateral hyp. - increase heart rate

Preoptic - decreases heart rate

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11
Q

Functions of descending reticular formation

A
  1. Regulation of muscle tone, movements, posture
  2. Modulation of pain transmission
  3. Visceral function
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12
Q

Functions of ascending reticular formation

A
  1. Alertness, sleep, wakefulness
  2. Appreciation and discrimination of sensations
  3. Genesis of EEG
  4. Learning and memory
  5. Neuroendocrine secretion
  6. Focusing attention on sensations
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13
Q

Applied physiology for reticular formation

A
  1. Anasthetics block ARAS
  2. Amphetamines, adrenaline activate ARAS
  3. Damage to ARAS causes coma
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14
Q

Modulation of pain by which pathways

A
  1. Serotonergic from raphae nucleus
  2. Dopaminergic from substantia Niagra
  3. Noradrenergic from locus ceruleus
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15
Q

Functions of limbic system

A
  1. Controls autonomic functions
  2. Feeding behaviour
  3. Memory and learning
  4. Emotional behaviour
  5. Sexual behaviour
  6. Olfaction
  7. Maternal behaviour
  8. Reward and punishment
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16
Q

Inhibit emotions

A

Cerebral cortex
VMN
Septal nuclei