CNS General Flashcards
Input to hypothalamus
Amygdala Hippocampus Thalamus Prefrontal cortex Olfactory cortex Tegmentum Striatum
Output from hypothalamus
Tegmentum Thalamus ANS Brainstem centres Hypophysis Subthalamic body Reticular formation Limbic system
Food intake hypothalamus
VMN(glucostats) - satiety centre - inhibits food intake
LN - Feeding centre - increases food intake
-increase in blood glucose activates VMN in post prandial state
Peptides influencing food intake
Increasing
- Neuropeptide Y - by arcuate nucleus
- Orexin A and B - by lateral hypothalamus
- Ghrelin - stomach and hypothalamus
Decreasing
- MSH
- CRH
- ACTH
Leptin
- produced by adipose tissue
- secretion proportional to size of fat depot
- inhibits food intake
- long term regulation
- deficiency causes obesity
Gut peptide theory
CCK, glucagon, somatostatin, GRP secreted by gut inhibit food intake
Thermostatic theory of food regulation
Fall in core temp. Increases appetite and vice versa
Regulation of body temp by hypothalamus
Preoptic nuclei
Anterior hypothalamus
Posterior hypothalamus
- preoptic nuclei have temperature sensors that detect through blood flowing through hyp., And by cutaneous receptors on cortex
- anterior hyp regulates in hot environment
- posterior hyp regulates in cold environment
Regulation of thirst by hypothalamus
Lateral hypothalamus
Preoptic area
- increased tonicity simulates osmoreceptors
- decreased ECF volume simulates baroreceptors and angiotensin ii
- angiotensin ii acts on subfornical organ
Cardiovascular regulation of hypothalamus
Posterior and lateral hyp. - increase heart rate
Preoptic - decreases heart rate
Functions of descending reticular formation
- Regulation of muscle tone, movements, posture
- Modulation of pain transmission
- Visceral function
Functions of ascending reticular formation
- Alertness, sleep, wakefulness
- Appreciation and discrimination of sensations
- Genesis of EEG
- Learning and memory
- Neuroendocrine secretion
- Focusing attention on sensations
Applied physiology for reticular formation
- Anasthetics block ARAS
- Amphetamines, adrenaline activate ARAS
- Damage to ARAS causes coma
Modulation of pain by which pathways
- Serotonergic from raphae nucleus
- Dopaminergic from substantia Niagra
- Noradrenergic from locus ceruleus
Functions of limbic system
- Controls autonomic functions
- Feeding behaviour
- Memory and learning
- Emotional behaviour
- Sexual behaviour
- Olfaction
- Maternal behaviour
- Reward and punishment