CNS Neoplasia

Question 1

Intra axial

Answer 1

comes from brain parencyma

Question 2

Intra-dural

Answer 2

Inside the dura, outside medullary cavity

Question 3

Clinical signs forebrain (5)

Answer 3

1. Seizures
2. behavioral changes
3. circling, head pressing
4. proprioceptive deficits
5. Cervical pain

Question 4

Clinical signs Brainstem (3)

Answer 4

1. Altered consciousness
2. Cranial nerve dysfunction
3. Gait abn +/- proprioceptive deficits

Question 5

Clinical signs Cerebellum (5)

Answer 5

1. Cerebellar ataxia
2. Intention tremors
3. Vestibular dysfunction
4. Menace deficits
5. Normal vision

Question 6

Clinical signs Spinal cord (3)

Answer 6

1. +/- pain
2. quadra/tetra paresis/plegia
3. Decreased reflexes if at intumescence
   - C6-T2
   - L2-S2

Question 7

Primary brain tumors

Answer 7

1. Meningioma
2. Glioma
3. Choroid Plexus Tumors
4. Lymphoma
5. Histiocytic Sarcoma
   * Goldens and Boxers

Question 8

Dog older than 7 yo with first seizure

Answer 8

be suspicious of brain tumor

Question 9

Most common feline intracranial neoplasia

Answer 9

Meningioma

Question 10

Brain tumor tx (conservative/palliative) (3)

Answer 10

Conservative/Palliative

1. Hyperosmolar agents
2. Anticonvulsants
3. Anti-inflammatory pred

Question 11

Brain tumor definitive tx (6)

Answer 11

1. Surgical debulking (can take cortex I think)
2. Chemo
3. Radiotherapy
4. Radiosurgery
5. Gene therapy
6. Immunotherapy

Question 12

Surgery feline meningiomas (3)

Answer 12

1. Treatment of choice-good prog for surgery alone
   - MST 21-27 months
2. Well encapsulated
3. Often curative

Question 13

Surgery Canine Meningiomas (2)

Answer 13

1. Complete surgical excision difficult
2. Radiation recommended post op (or as main tx)
   - MST sx: 0.5-3.5 yrs, Radiation: ~1yr, Sx and radiation: 1.5 yrs

Question 14

Surgery gliomas (2)

Answer 14

1. Infiltrate, so debulking difficult
2. Radiation typically recommended
   - MST radiation alone: 6mo

Question 15

Cancers that commonly met to brain (6)

Answer 15

1. Urogenital carcinomas
2. Pulmonary carcinomas
3. HSA
4. Malignant melanoma
5. Lymphoma
6. Histiocytic Sarcoma

Question 16

Origin of spinal tumors (4)

Answer 16

1. Vertebrae
2. Meninges
3. Parenchymal
4. Vasculature

Question 17

Primary vertebral cancers (ush single vert) (4)

Answer 17

1. Osteosarc
2. Lyphoma
3. Fibrosarc/chondrosarc/hemangiosarc
4. Multiple myeloma

Question 18

Secondary vertebral tumors

Answer 18

1. Hemangiosarcoma
2. Thyroid carcinoma
3. prostatic carcinoma
4. mammary carcinoma

Question 19

Spinal Meningioma (4)

Answer 19

1. most common spinal cord tumor of dog
2. cranial to C3-boxers overrepresented
3. Tx: sx debulking & radiation
4. Prog: MST w/sx 19 mo

Question 20

Lymphoma (4)

Answer 20

1. anywhere in spine
2. Many are multicentric
3. young FeLV+ cats
4. 1/3 of spinal cord dz in cats

Question 21

Lymphoma tx

Answer 21

1. Chemo (NOT SX) MST <5-7 mo

2. Palliative (steroids)

Question 22

Peripheral Nerve Sheath Tumor

Answer 22

1. anwhere on nerve or nerve root
2. locally aggressive, rare in cats
3. lameness, atrophy, pain

Question 23

MPNST

Answer 23

1. malignant, has gone into spinal cord

2. Surgical resection-prog ~1mo if in spinal cord