CNS - lecture 4

Question 1

synaptic plasticity

Answer 1

alter the physiological strength of transmission

Question 2

changes in EPSP

Answer 2

measure of synaptic plasticity

Question 3

what do EPSP’s arrive form

Answer 3

activity at NMDA and AMPA receptors

Question 4

what 2 conditions do NMDARS need to conduct ions

Answer 4

postsynaptic depolarization and glutamate binding

Question 5

NMDARS

Answer 5

volateg dependant. chemically gated channels. Coincidence detectors

Question 6

AMPARS

Answer 6

conduct sodiun ions to depolarize the cell

Question 7

CaMK11

Answer 7

protein kinases, increased calcium causes activation (unphosphorlated to phosphorylated)

Question 8

Key expression of LTP

Answer 8

inserting more AMPARS (like adding more mics at a concert)

Question 9

Expression of LTP

Answer 9

NMDA receptors are unbloked by depolarization and Ca enters, more AMPA receptors are inserted after Ca influx occurs, LTP is expressed

Question 10

how does experience effect spines

Answer 10

they change, some grow some are lost

Question 11

blocking NMDA receptors after environment experience

Answer 11

no effect on place cell activity

Question 12

blocking NMDA receptors durning memory encoding

Answer 12

prevents formation of place cells in this environment (no memory of being here before)

Question 13

Spatial memory blocking NMDA receptors

Answer 13

no idea where previous landmarks are, no spatial memory