Cell Physiology - cellular organelles - Pathophysiology

Question 1

ribosomopathy

Answer 1

abnormalities in ribosomal biogenisis resulting in human disease

Question 2

ER stress

Answer 2

secondary to other disease, altered Er function results in accumulation of unfolded/misfoled proteins, triggers Unfoled protein response (UPR), can cause apoptosis.

Question 3

mitochondria disease

Answer 3

primary or secondary, complex, various phenotypes

Question 4

lysomosomes storage disorders

Answer 4

toxic material builds up in lysosomes, over 70 types

Question 5

peroxisomes biogenesis disorders

Answer 5

linked to PEX family of genes, PEX proteins are required for peroxisomes biogenisis