CNS Infections

Question 1

Presence of inflammatory cells in the CSF

Answer 1

Pleocytosis

Question 2

Meningitis is said to be chronic when onset of symptoms is said to be over

Answer 2

4 weeks

Question 3

What is Aseptic Meningitis

Answer 3

Syndrome consistent with signs and symptoms of meninges inflammation but negative routine CSF cultures

Question 4

Risk factors for acquiring meningitis

Answer 4

Extremes of Age(<5 years or >60 years)
Immunosuppression
Overcrowding/poor housing
Sickle cell disease and/or splenectomy
IV drug Abuse
Bacterial Endocarditis
Dural defect
Ventriculoperitoneal Shunt

Question 5

What is the major etiologic bacteria in meningitis in Age 0 to 4weeks

Answer 5

S.agalactiae, E.coli, L.monocytogenes

Question 6

What is the major etiologic bacteria in meningitis in ages 3months to 18 years

Answer 6

N.meningitidis, S.pneumoniae, H.Influenzae

Question 7

What is the major etiologic bacteria in meningitis in 18 years to 50years

Answer 7

S.pneumoniae, N.meningitidis, H.influenzae

Question 8

What is the major etiologic bacteria in meningitis in immunocompromised patients

Answer 8

S.pneumoniae
N.meningitidis
L.monocytogenes
Aerobic Gram negative bacilli

Question 9

What is the major etiologic bacteria in meningitis in intracranial manipulation and CSF shunt

Answer 9

Coagulese-negative staphylococci, S.aureus, aerobic gram-negative bacilli

Question 10

Increased intracranial pressure and cerebral fluid may result from the following pathways

Answer 10

Interstitial edema from obstruction of CSF flow due to increased viscosity of CSF

Cytotoxic edema from released toxic factors from bacteria and neutrophils

Vasogenic edema from increased blood brain barrier permeability (with accompanying increase in CSF protein)