CNS Drug List

Question 1

what is the glutamate receptor and what is its mechanism?

Answer 1

NMDA and ^ Ca2+, Na2+, K+ conductance

Question 2

what drugs decrease NMDA release?

Answer 2

morphone, heroin, and THC

Question 3

what drugs decrease NMDA receptor activation

Answer 3

PCP

Ethanol

Question 4

What are the two receptors associated with Acetylcholine?

Answer 4

M and N

Question 5

what is the mechanism of Acetycholine?

Answer 5

G-protein linked: ^ IP3, ^ DAG, and decrease K+ conductance

Ion channels: ^ Na+, K+ conductance

Question 6

what is a direct agonist for acetylcholine, and an antagonist?

Answer 6

agonist: donepezil
antagonist: benztroine

Question 7

what are two inhibitory neurotransmitters?

Answer 7

GABA and Dopamine

Question 8

what are the two GABA receptros, and what is the mechanism of GABA?

Answer 8

a and b
ionchannel: ^ CL- conductance
G-protein: ^K+conductance

Question 9

what decreases the release of GABA?

Answer 9

THC, morphine and Heroin

Question 10

what do these 3 drugs do?
dizapam
phenobartial
ethanol?

Answer 10

Increase GABAa receptor activation

Question 11

what is the receptor and mechanism of Dopamine?

Answer 11

D2
Presynatic: G-protein -> decrease Ca+2 conductance
postsynaptic: G-protein -> ^ K+ conducntance and decrease cAMP

Question 12

what drug increases dopamine synthesis?

Answer 12

L-DOPA

Question 13

what drug increases dopamine release?

Answer 13

amphetamine

Question 14

what drug decreases dopamine reuptake?

Answer 14

cocaine

Question 15

what drug decreases dopamine metabolism?

Answer 15

phenelzine and selegiline

Question 16

what is a D2 agonist?

Answer 16

ropinirole

Question 17

what is a D2 antagonist?

Answer 17

haloperiode

olanzapine

Question 18

what is the cause of AD? (alzheimers Disease)

Answer 18

loss of cholinergic projection neurons,

Question 19

what is the cause of Parkinsons Dieaseas?

Answer 19

loss of nigro-striatal dopamine projection neurons

Question 20

how is dopamine linked to psychosis and schizophrenia?

Answer 20

excess dopamine neurotransmission in limbic system

Question 21

name the 3 receptors and linked mechanism to norepinephrine

Answer 21

alpha1-> g-protein: ^IP3, ^DAG, ˇK+ conductance
alpha2-> g-protein: ˇcAMP
beta1 -> g-protein:^ cAMP

Question 22

what increases norepinephrine release?

Answer 22

amphetamine

tyramine

Question 23

what decreases norepinephrine release?

Answer 23

morphine

heroine

Question 24

what decreases norepineprhine reuptake?

Answer 24

imipramine

cocaine

Question 25

what decreases the rate of norepinephrine metabolism?

Answer 25

phenelzine

Question 26

what receptors are associated to serotonin and what are their mechanisms?

Answer 26

5HT1a- G-protein: ˇcAMP, ^K+

5HT2a- G-proteinL ^IP3, ^DAG, ˇ K+

Question 27

what increases serotonin release?

Answer 27

amphetamine

Question 28

what decreases the reuptake of serotonin?

Answer 28

imipramine
fluoxetine
cocaine

Question 29

what decreases the metabolism of serotonin?

Answer 29

phenelzine

Question 30

what is a 5-HT2a partial agonist?

Answer 30

LSD

Question 31

what is a 5-HT2A antagonist?

Answer 31

haloperidol

olanzapine

Question 32

what reduced [neurotransmission] is linked to depression?

Answer 32

monoamine

Question 33

what is an mu agonist? And what drug is it linked to?

Answer 33

Opioids

heroin, morphine, methadone

Question 34

what is a my antagonist?

Answer 34

naloxone

Question 35

what receptor is prefered for olanzapine?

Answer 35

5-HT2a>D2

Question 36

what receptor is preferred for haloperidol?

Answer 36

D2> 5-HT2z

Question 37

what does bupropion do?

Answer 37

mechanism not clearly understood, but it weakly inhibits reuptake and stimulates release of NE and dopamine

Question 38

how do methanol and ethanol mix?

Answer 38

methanol competes with ethanol for metabolism. ethanol is used to treat methanol overdose.**