CNS Drug List Flashcards
what is the glutamate receptor and what is its mechanism?
NMDA and ^ Ca2+, Na2+, K+ conductance
what drugs decrease NMDA release?
morphone, heroin, and THC
what drugs decrease NMDA receptor activation
PCP
Ethanol
What are the two receptors associated with Acetylcholine?
M and N
what is the mechanism of Acetycholine?
G-protein linked: ^ IP3, ^ DAG, and decrease K+ conductance
Ion channels: ^ Na+, K+ conductance
what is a direct agonist for acetylcholine, and an antagonist?
agonist: donepezil
antagonist: benztroine
what are two inhibitory neurotransmitters?
GABA and Dopamine
what are the two GABA receptros, and what is the mechanism of GABA?
a and b
ionchannel: ^ CL- conductance
G-protein: ^K+conductance
what decreases the release of GABA?
THC, morphine and Heroin
what do these 3 drugs do?
dizapam
phenobartial
ethanol?
Increase GABAa receptor activation
what is the receptor and mechanism of Dopamine?
D2
Presynatic: G-protein -> decrease Ca+2 conductance
postsynaptic: G-protein -> ^ K+ conducntance and decrease cAMP
what drug increases dopamine synthesis?
L-DOPA
what drug increases dopamine release?
amphetamine
what drug decreases dopamine reuptake?
cocaine
what drug decreases dopamine metabolism?
phenelzine and selegiline
what is a D2 agonist?
ropinirole
what is a D2 antagonist?
haloperiode
olanzapine
what is the cause of AD? (alzheimers Disease)
loss of cholinergic projection neurons,
what is the cause of Parkinsons Dieaseas?
loss of nigro-striatal dopamine projection neurons
how is dopamine linked to psychosis and schizophrenia?
excess dopamine neurotransmission in limbic system
name the 3 receptors and linked mechanism to norepinephrine
alpha1-> g-protein: ^IP3, ^DAG, ˇK+ conductance
alpha2-> g-protein: ˇcAMP
beta1 -> g-protein:^ cAMP
what increases norepinephrine release?
amphetamine
tyramine
what decreases norepinephrine release?
morphine
heroine
what decreases norepineprhine reuptake?
imipramine
cocaine
what decreases the rate of norepinephrine metabolism?
phenelzine
what receptors are associated to serotonin and what are their mechanisms?
5HT1a- G-protein: ˇcAMP, ^K+
5HT2a- G-proteinL ^IP3, ^DAG, ˇ K+
what increases serotonin release?
amphetamine
what decreases the reuptake of serotonin?
imipramine
fluoxetine
cocaine
what decreases the metabolism of serotonin?
phenelzine
what is a 5-HT2a partial agonist?
LSD
what is a 5-HT2A antagonist?
haloperidol
olanzapine
what reduced [neurotransmission] is linked to depression?
monoamine
what is an mu agonist? And what drug is it linked to?
Opioids
heroin, morphine, methadone
what is a my antagonist?
naloxone
what receptor is prefered for olanzapine?
5-HT2a>D2
what receptor is preferred for haloperidol?
D2> 5-HT2z
what does bupropion do?
mechanism not clearly understood, but it weakly inhibits reuptake and stimulates release of NE and dopamine
how do methanol and ethanol mix?
methanol competes with ethanol for metabolism. ethanol is used to treat methanol overdose.**
