CNS Depressants

Question 1

Depressants

Answer 1

drugs that reduce neuronal activity in the brain, target GABA receptor

Question 2

GABA receptors

Answer 2

promote hyperpolarization of the postsynaptic cell

Question 3

Orthosteric site

Answer 3

where GABA normally binds to the receptor, primary binding site

Question 4

Allosteric modulators

Answer 4

change the functionality of the orthostatic site without competing for the same site

Question 5

Barbituates

Answer 5

potent sedative-hypnotic drugs widely used in early 1900s, used to induce sleep in psychotic patients and to treat insomnia and anxiety

Question 6

Long acting barbituates

Answer 6

low lipid solubility, slowly absored

Question 7

Intermediate and short acting barbituates

Answer 7

moderate lipid solubility, absorbed faster with a 30 minute onset aciton

Question 8

Ultrashort acting barbituates

Answer 8

highest lipid solubility, time to action mere minutes, lasting effects of about 30 minutes

Question 9

REM suppression

Answer 9

reduces quality of sleep

Question 10

REM rebound

Answer 10

reduces quality of sleep by repeated nightmares

Question 11

GHB and GABA

Answer 11

each is a precursor and a by-product of each other

Question 12

Sudden sniffing death syndrome

Answer 12

inhalants causing immediate arrhythmias and cardiac arrest