CNS and PNS Flashcards
Between what pressures is cerebral autoregulation maintained
CPP (not MAP) of 50-150
How does CSF flow from the lateral ventricles to the 3rd ventricle?
Foramen of Monro
How does CSF flow from the 3rd ventricle to the 4th ventricle?
Aqueduct of Sylvius
How does CSF flow out of the 4th ventricle?
The midline foramen of Magendie and the lateral foraminae of Luschka
How much does CBF change with hyperventilation?
1 mL / 100 g / min increase or decrease for every 1 mmHg increase or decrease of PaCO2 from 40
Below what value of PaCO2 is hyperventilation no longer beneficial for reducing ICP?
no ICP benefit below 25
can cause cerebral ischemia if PaCO2
What hemodynamic response is seen with brain herniation?
First, Cushing’s triad: HTN, bradycardia, and irregular respirations with elevated ICP
Then, hypotension when tonsilar herniation begins
Which anesthetics cause cerebral vasodilatation? Cerebral vasoconstriction?
Vasodilatation: ketamine and volatile anesthetics
Vasoconstriction: propofol, etomidate, opioids
What do beta agonists do to CMRO2 and CBF?
Increase both
How long does it take for extra-junctional AChRs to develop after a neurologic injury?
2-3 days
What do barbiturates do to CMRO2?
reduce CMRO2 - previously utilized in “barbiturate coma” for cerebral protection
What is the only inhaled anesthetic to increased CMRO2?
nitrous oxide
Which inhaled anesthetics cause the greatest reduction in seizures?
desflurane > isoflurane
Which inhaled anesthetic is associated with an increased risk of seizures?
enflurane
What sensory modalities do A-alpha fibers carry? A-beta? A-delta? C?
A-alpha - proprioception
A-beta - touch/pressure
A-delta - temperature, sharp pain
C - dull pain, temperature (warm), touch