CNS anatomy Flashcards
what are the two parts of the CNS
visceral and somatic
what is the somatic part
recieving and responding to information from the external environment
what is the visceral part
innervation of organs in the body and other components, more connected with the internal
what does the CNS do
controls and coordinates most functions of the body and mind
what does the CNS include
spinal cord and brain
role of CSF
supports and protects the brain and spinal cord by maintaining uniform pressure
shock absorber between brain and skull
keeps brain and SC moist
exchange of nutrients and waste between CSF and interstitial fluid
acts as a cushion for the brain, making it weightless
keeps the brain in place
regulation of breathing, bathes the medulla where the central respiratory chemoreceptors are found
what does CSF contain
glucose [gives it a slight yellow colour], lactic acid and proteins
where does CSF exit
through the meninges into the venous supply
what happens to CSF if brain is enlarged
fluid levels decrease
what happens if the brain volume decreases
CSF levels increase
what allows for the secretion of CSF into each ventricle
choroid plexus [highly vascularised]
what cells is the CSF surrounded by
ependymal cells
how does CSF pass back into the blood
by the arachnoid villi, composed of arachnoid matter which project into the venous sinuses
what does the movement of CSF depend on
the pressure at each side of the villi walls, transferring it from the arachnoid space to the venous sinuses
what happens to the CSF movement if CSF pressure is higher than venous pressure
CSF pushed into the blood
what happens if the venous pressure is greater
the arachnoid villi collapse preventing passage of blood constituents into CSF
formanen of monro
sits behind part of the BS
from 4th to SC
reabsorbed back into circulation via meninges
what is the blood supply
circulus arteriosus + arteries maintain constant supply of oxygen and glucose to the brain, when the head moves, the contributing artery becomes narrowed
autoregulation of cerebral arteriolar diameter maintains constant blood flow to the brain compensating for fluctuations, protecting the brain
venous blood drains into the dural venous sinuses -> IJ vein
what should the systemic BP be
65-140mmHg
what is the arterial blood supply
carotid feeds through the neck
vertebral + internal carotid = connected in the inter cranial space = cerebral arterial circle of willis
two vertebral arteries enter the cranial cavity through the foramen magnum forming the basillar artery
what causes a stroke
blockage of blood to the brain
what causes a haemorrhage
over blood supply
what causes vascular dementia
diameter constriction, less blood to brain causes confusion
what are the four ventricles
left
right
3rd
4th
where are the lateral ventricles
in the central hemisphere on each side of the median plane below the corpus callosum
separated by a narrow septum and lined with ciliated epithelium
what do the lateral ventricles communicate with
the 3rd ventricle via the inter-ventricular foramen
where is the 3rd ventricle found
below the lateral ventricles, between the 2 parts of the thalamus
what does the 3rd ventricle communicate with
the 4th by the canal aqueduct, it recieves CSF fluid via the cerebral aqueduct
where is the 4th ventricle
sits below and behind the 3rd between the cerebellum and the pons
slightly alkaline and has a specific gravity of 1.005
consists of water, salts, glucose, plasma proteins, leukocytes, creatinine, urea
what is hydrocephallis
blocked ventricle, excess CSF which builds up, failing to reabsorb
causes intracranial pressure and can link to meninge issues
how do CSF leaks present
headaches, relief whilst laying down
lack of CSF can cause collapse, as brain becomes heavy
CSF leak SE
nausea, headaches, confusion, vomiting, clear fluid from ear and injury site
what is the BBB
it is a semipermeable barrier which allows small molecules in via diffusion as well as selective + AT of various nutrients and ions and anions and macromolecules
protects the brain tissue from pathogens + toxic substances
what cant pass through the BBB
chemo BUT TEMZ
however a reservoir can be put in so that small doses of chemo can be given
what can pass through the BBB
oxygen, carbon dioxide, glucose, lipid soluble
inorganic ions, AA pass slowly or not at all
what are the two types of cell of the brain
neurons and glial
what is a feature about neurones
THEY DONT DIVIDE
ONCE THEY DIE THEY CANT BE REPLACED
what do sensory neurons do
detect stimuli from external
what do motor neurones do
carry impulses from brain to muscles
what do interneurones do
connect other nerve cells and help relay messages between the brain and other body cells. They allow impulses from sensory neurons -> brain -> motor
what structures are grey matter
brain, BS, cerebellum, SC
what is GM
six layers of neurons, axon terminals and dendrites
what does grey matter do
send nerve signals which govern motor activity to nervous system
what does white matter do
myelinated, conductor of nerve signals which process them
conducts, sends and processes signals and responds
there is more white matter so signals can respond after they’ve been replaced
what are the different glial cells
ependymal
astrocytes
oliogodendrocyte
microglia
what is the role of the glial cells
support the neurones and protect them
regulate chemical environment
role repair in trauma
what is the role of astrocytes
clean up dead neurons
fine branching processes lie in a mucopolyssacharide ground substance
biochemical control which line the BBB
tells the transmitters what to do after the message has been delivered
contributes to homeostasis
structural support of CNS
linked with parkinsons
what happens when the astrocytes get damaged
the processes form a mesh as they multiply, which inhibits regrowth of damaged CNS neurones
what are ependymal cells
hair like projections which move CSF fluid through fluid filled cavities, which form the lining of the ventricles and the central canal of the SC
what would happen if there was no ependymal cells
build up of fluid would occur
what do specialised ependymal cells form
choroid plexuses of the ventricles and secrete CSF
what are oligodendrocytes
cluster of nerve cells bodies in grey matter which are found adjacent to and along the mylelinated nerve fibres
what do the oligodendrocytes form
the myelin sheath around the neurons, faster transmission of information sending, also contains multiple branches which speeds up transmission also.
it protects the neurons, and the gap allows for conduction and impulse of messages, which multiply around degenerating neurones
how are oligodendrocytes destroyed
in demyelinating diseases
what are microglia
cells derived from monocytes which migrate from the blood to the nervous system. Which remove damaged and infected cells maintaining CSF is a healthy state
static cells are found dispersed throughout the brain
what are microglia part of
the mononulear phagocyte system
what are the types of meninges
cranial
spinal
what do meninges do
they stop the brain/cord from touching bone, contains a blood supply, produces CSF
where are meninges
lie in between the skull and the brain, and between the vertebral foramina and spinal cord
brain and SC are completely surrounded by three layers of tissue
what are the 3 layers of tissue
[outwards - in]
dura mater
arachnoid mater
pia mater
what is found between the dura mater and the arachnoid mater
subdural space - serous fluid
what is found between the arachnoid mater and pia mater
subarachnoid space = contains CSF
these 3 layers continue in the…..
spinal canal, containing the epidural space
what is dura mater composed of
two layers of dense fibrous tissue
outer periosteal layer lines the inner surface of the skull, bones and inner meningeal layer, provides a protective covering.