CNS Flashcards
Two main tracers sued for brain SPECT
Tc HMPAO (hexamethylpropyleneamine oxime); Tc ECD (ethyl cysteinate dimer)
Difference in kinetics of HMPAO an ECD
HMPAO washout is fast, ECD washout is slow
What are the similarities between HMPAO and ECD?
neutral and lipophilic (cross BBB) and both accumulate in the cortex proportional to blood flow
distribution of HMPAO
uptake favors the frontal lobe, thalamus, and cerebellum
CNS radiotracer with uptake in the frontal lobe, thalamus, and cerebellum
HMPAO
distribution of ECD
parietal and occipital lobes
CNS radiotracer with uptake in the parietal and occipital lobes
ECD
Radiotracer used to evaluate cerebral vascular flow, but not taken up by brain parenchyma
Tc DTPA. does NOT cross the BBB
for imaging of a seizure focus, when does the HMPAO or ECD need to be injected?
30 seconds of the seizure to get a good study
Alzheimer disease
corticobasal degeneration
frontotemporal dementia
frontotemporal dementia