CNS Flashcards
Amyloid precursor protein APP that
A. Function as receptor for prion protein
B. Gene that encodes APP is … familial alzheimer’s disease
C. Generates the AB peptide that cause the neuronal dysfunction in AD
D. Stimulates neuronophagia around the affected neurons
E. A, B, C are correct
E. A, B, C are correct
Clinical criteria of brain death
A. Symptoms of brain stem damage (absent reflexes and respiratory drive)
B. Axonal reaction are sprouting
C. Isoelectric or flat EEG
D. Neuronal inclusion and intracytoplasmic calcific accumulation in MRI
E. A and C
E. A and C
The following examination allow for the identification of pre-clinical stage of Alzheimer’s disease except:
A. AB deposition in the brain by imaging methods
B. Elevated phosphorylated tau in CSF
C. Elevated AB in the CSF
D. Decreased AB in the CSF
E. No exception. All are correct
C. Elevated AB in the CSF
Most important histolo-pathologic indicator of CNS injury
A. Prions
B. Glial fibrillary acidic protein (GFAP)
C. Neurofibrillary tangles
D. Gliosis
D. Plaques
D. Gliosis
Presumptive diagnosis of parkinson disease can be made when the triad of symptoms is present
- Rigidity tremor, bradykinesia
- Masked facies, tremors, rigidity
- Bradykinesia, tremors
- Festinating gait, bradykinesia, pill rolling tremors
- Rigidity, festinating gait, tremors
- Rigidity tremor, bradykinesia
RESPONSE OF CNS TO INJURY:
Congregate around tissue necrosis and dying neuorons
a. Ependymal cells
b. Microglia
c. Oligodendrocytes
d. Astrocytes
e. Axons
B. Microglia
RESPONSE OF CNS TO INJURY:
Formation of irregularities or granulation in the ventricular surface
a. Ependymal cells
b. Microglia
c. Oligodendrocytes
d. Astrocytes
e. Axons
A. Ependymal cells
RESPONSE OF CNS TO INJURY:
Harbor viral inclusions and glial cytoplasmic inclusions by apoptosis
a. Ependymal cells
b. Microglia
c. Oligodendrocytes
d. Astrocytes
e. Axons
C. Oligodendrocytes
RESPONSE OF CNS TO INJURY:
Hypertrophy and enlargement of the nucleus and formation of intranuclear glycogen droplet (hyperammonia, Wilson disease)
a. Ependymal cells
b. Microglia
c. Oligodendrocytes
d. Astrocytes
e. Axons
D. Astrocytes
INTRACRANIAL HEMORRHAGE AND TRAUMATIC INJURY:
a. Cerebral amyloid angiopathy
b. Subdural hemorrhage
c. Epidural hemorrhage
d. Counter coup contusion
e. Coup lesion
Develop when the brain strikes the opposite inner surface of the skull after sudden
deceleration
D. Counter coup contusion
INTRACRANIAL HEMORRHAGE AND TRAUMATIC INJURY:
a. Cerebral amyloid angiopathy
b. Subdural hemorrhage
c. Epidural hemorrhage
d. Counter coup contusion
e. Coup lesion
Bleeding from torn bridging veins from cerebral hemisphere through the subarachnoid
space and subdural space—
B. Subdural hemorrhage
INTRACRANIAL HEMORRHAGE AND TRAUMATIC INJURY:
a. Cerebral amyloid angiopathy
b. Subdural hemorrhage
c. Epidural hemorrhage
d. Counter coup contusion
e. Coup lesion
Lobar hemorrhages in the cerebral cortex and leptomeninges
A. Cerebral amyloid angiopathy
INTRACRANIAL HEMORRHAGE AND TRAUMATIC INJURY:
a. Cerebral amyloid angiopathy
b. Subdural hemorrhage
c. Epidural hemorrhage
d. Counter coup contusion
e. Coup lesion
Bleeding from torn middle meningeal artery in temporal skull fracture that cross the course of the vessel
C. Epidural hemorrhage
INTRACRANIAL HEMORRHAGE AND TRAUMATIC INJURY:
a. Cerebral amyloid angiopathy
b. Subdural hemorrhage
c. Epidural hemorrhage
d. Counter coup contusion
e. Coup lesion
Accumulation of blood between inner and outer layer of the dura
C. Epidural hemorrhage
