CNS Flashcards
what is an anti-physotic used for?
treat schizophrenia
What is the side affect of the first generation anti-pysc drugs?
can form tardive dyskinesia
what is tardive dyskinsia
sudden jerky movement of the body and the face
what is the MOA of generation 1 anti pysch drugs?
block dopamine release
What is the function of 2 gen anti pysch drugs?
block dopa and serotonin release without the side effects of 1 gen
What is the function and MOA of SSRI
anti-dpressant through leaving more serotonin in the synapse
fluoxetine
Citalopram
Trazodone
What is the unction and MOA of SNRI/ TCA
serotonin and NE reuptake inhibitor
leave more in synapse
amitriptyline and Imipramine
what is a monoamine oxidase inhibitor
it is an antidepressant that inhibits the cleansing of the synapse
phenelzine
tranylcypromine
What is the drug of choice for manic depression (bipolar disorder)
lithium
what is an anxiolytic
for anxiety/ sedation
what are the two main axiolytics
benzodiazepines and barbiturates
Do either benzo or barbs help with pain
NOOOOO
What receptor do Benzos and Barbs work on?
GABA to slow down CNS
Which has more negative side effects benzo or barbs
barbs with respitory supression
What is the ideal drug for oral sedation in the dental setting
Benzos
diazepam
triazolam
chlordiazepoxide
With benzos, what can induce thrombophlebitis in large veins
propylene glycol
which disease which disease are barbs contra indicated in because they will worsen the disease?
intermittent porphyria
What does a barb overdose cause?
respiratory depression
With general anesthesia what is the role of solubility in blood
more soluble the more drug is needed for effect
What is stage i of General Anesthetics
analgeisa/ feleing better not fully asleep
What is stage ii of General Anesthetics
delierium, undesriable
What is stage iii of General Anesthetics
sugrical ansethsia
What is stage iv of General Anesthetics
meduallry paralysis (OD)
What is the cause of parkinson’s disease c
dopamine deficincy
how is parkinson’s treated?
dopamine cannot cross BBB but LEVODOPA can, but it can be inactivated quickly so must be paried with CARBidopa so it can cross the BBB
what does CARBIDOPA block?
dopa decarboxylase
