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Block 11 - Multisystems > CM: Inflammatory Dermatoses > Flashcards

CM: Inflammatory Dermatoses Flashcards

1
Q

normal epidermis
infiltrate around blood vessels in superficial plexus
blood vessels dilated

A

superficial perivascular dermatitis w/o epidermal change

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2
Q

What is the clinical presentation of superficial perivascular dermatitis w/o epidermal change?

A

erythematous macules and patches, papules and plaques

normal epidermis –> smooth skin surface

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3
Q

What kinds of skin diseases commonly show a superficial perivascular dermatitis w/o epidermal change pattern?

A

viral exanthems

drug eruptions of morbilliform type (7-14 days after)

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4
Q

thickened stratum corneum = parakeratosis

alteration of dermoepidermal jxn by infiltrate

A

superficial perivascular dermatitis w interface change

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5
Q

What are the two types of superficial perivascular dermatitis w interface change?

A

vacuolar subtype - interface altered by vacuolated basal cells as result of inflammation
lichenoid subtype - lichen planus like, band of lymphocytes obscures interface

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6
Q

What is the clinical presentation of superficial perivascular dermatitis w interface change?

A

erythema, violaceous

papules and plaques, scale

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7
Q

What skin diseases commonly show superficial perivascular inflammation w interface change?

A

EM, dermatomyositis, lichen planus, mycosis fungoides, cutaneous t cell lymphoma

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8
Q

spongiosis
serum and inflammatory cells in stratum corneum
acanthosis and parakeratosis
superficial perivascular infiltrate

A

superficial perivascular dermatitis w spongiosis

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9
Q

What is the clinical presentation of superficial perivascular dermatitis w spongiosis?

A

erythema, papules and plaques, crust

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10
Q

Which skin diseases present w superficial perivascular dermatitis w spongiosis?

A

allergic contact dermatitis
nummular dermatitis
tinea inf

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11
Q

superficial perivascular infiltrate
epidermal hyperplasia due to elongation of thinned rete ridges
diminished granular layer and parakeratosis
thin epidermis above widened capillaries
neutrophils in stratum corneum or spinous layer

A

superficial perivascular dermatitis w psoriasiform hyperplasia

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12
Q

What is the clinical presentation of superficial perivascular dermatitis w psoriasiform hyperplasia?

A

erythema, papules and plaques, sharp circumscription of lesions, (silver) scale

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13
Q

What are skin diseases that show superficial perivascular dermatitis w psoriasiform hyperplasia?

A

psoriasis

lichen simplex chronicus

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14
Q

inflammatory cells in superficial and deep vascular plexuses in dermis
variable changes in epidermis

A

superficial and deep perivascular dermatitis

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15
Q

What is the clinical presentation of superficial and deep perivascular dermatitis?

A

erythema, papules and plaques, indurated due to deeper inflammation

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16
Q

What are skin diseases that present w superficial and deep perivascular dermatitis?

A 
lupus and dermatomyositis (interface change)
secondary syph (psoriasiform + lichenoid changes)
arthropod bite rxn (maybe spongiosis)
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17
Q

perivascular aggregates of inflammatory cells around superficial and deep vascular plexi
extensive coalescence of nodular aggregates to form sheets
possible granulomas

A

nodular and diffuse dermatitis

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18
Q

What is the clinical correlation of nodular and diffuse dermatitis?

A

reddish-brown granulomatous infiltrates by exam
yellow-brown infiltrates on diascopy
erythematous non-granulomatous infiltrates
papules, nodules, plaques

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19
Q

What are skin diseases that show a nodular and diffuse dermatitis pattern?

A

Hansen’s dz, tb, sarcoidosis, sweet syndrome, b-cell lymphoma

20
Q

*blood vessel injury or destruction

A

vasculitis

21
Q

What are the different kinds of vasculitis?

A

small vessel: leukocytoclasis = perivascular neutrophilic infiltrate, extravasated erythrocytes, fibrinoid degeneration, endothelial cell necrosis
medium and large vessel

22
Q

What is the clinical correlation of vasculitis?

A

purpura
small vessel: purpuric macules, patches, papules, plaques
medium vessel: papulonodules

23
Q

What are the skin diseases that present w vasculitis?

A

leukocytoclastic vasculitis, PN, Wegener’s

24
Q

vesicles w/i epidermis
acantholysis
ballooning degeneration
spongiosis

A

intraepidermal vesicular dermatitis

25
Q

What is the clinical correlation of intraepidermal vesicular dermatitis?

A

translucent vesicle or bulla

erythema

26
Q

What are skin diseases that present w intraepidermal vesicular dermatitis?

A

pemphigus vulgarus
herpes
impetigo
allergic contact dermatitis

27
Q

vesicles beneath epidermis

sometimes superficial perivascular inflammation in dermis

A

subepidermal vesicular dermatitis

28
Q

What is the clinical correlation of subepidermal vesicular dermatitis?

A

translucent vesicle or bullae, erythema at base of blister
thicker roof = tense bullae
loss of roof = erosions

29
Q

What are skin dzs that show subepidermal vesicular dermatitis?

A

bullous pemphigoid
dermatitis herpatiformis
porphyria cutanea tarda

30
Q

alteration in quality and quantity of collagen

fibrosis w increase in fibrocytes, sclerosis w decrease in fibrocytes

A

fibrosing and/or sclerosing dermatitis

31
Q

What is the clinical correlation of fibrosing and/or sclerosing dermatitis?

A

erythema and violaceous border of active inflammation
papules and plaques from increased collagen
depressed plaques from decreased collagen

32
Q

What are skin dzs that show a fibrosing or sclerosing dermatitis?

A

scar, keloid, morphea, scleroderma

33
Q

inflammatory cells w/i follicle

follicular pustule

A

folliculitis

34
Q

inflammatory cells around follicle
granulomatous
lymphocytic

A

perifolliculitis

35
Q

What is the clinical correlate of folliculitis/perifolliculitis?

A

erythema, yellow or creamy pustules
follicular papules
papules or nodules

36
Q

What are skin diseases that show folliculitis/perifolliculitis?

A

acne vulgaris and hidradenitis suppurativa
rosacea
alopecia areata (just perifolliculitis)

37
Q

inflammatory cells in fibrous septa of subcutaneous fat

A

septal panniculitis (erythema nodosum)

38
Q

inflammatory cells present through lobules as well as septa of subcutaneous fat
foamy macrophages

A

lobular panniculitis (lupus profundus)

39
Q

What is the clinical correlate of panniculitis?

A

nodules and plaques w ill defined boundaries fixed to underlying fascia

40
Q

What does erythema correlate with?

A

inflammation (non-granulomatous) and vascular dilation

41
Q

What does scale correlate with?

A

hyperkeratosis/parakeratosis

42
Q

What does serous crust correlate with?

A

spongiosis, serum and inflammatory cells in stratum corneum, loss of epidermal barrier fxn

43
Q

What does deep inflammation correlate with?

A

induration

44
Q

What does flaccid blister correlate with?

A

intraepidermal vesicle

45
Q

What does tense blister correlate with?

A

subepidermal vesicle

46
Q

What does sclerotic abundant collagen extending throughout dermis correlate with?

A

hide bound skin

47
Q

What does ill-defined borders correlate with?

A

subcutaneous inflammation

Block 11 - Multisystems (29 decks)

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