clw 8 Flashcards
HF, hepatitis, liver cirrhosis, asthma, VTE
name 3 differential causes of dyspnoea
- fluid overload secondary to hfref
- asthma
- pulmonary embolism
- pneumonia
- lung cancer
- MI
- ascites due to liver cirrhosis
main sx of fluid overload secondary to HF
Orthopnoea - cannot breathe when lying down at night
telltale sx of ascites due to liver cirrhosis causing dyspnoea
palmar erythema
jaundice, ascites
pruritis
spider angiomata
lab results to look out for when liver has issues
elevated lft
coagulation tests (PT, aPTT, INR)
asthma sx
wheezing (auscultation)
SOB
chest tightness
unable to talk in sentences
elevated pulse rate
pulmonary embolism s/sx
d-dimer
unilateral pitting edema (dvt)
ssx of pneumonia
fever
cxr lung consolidation
chest pain
s/sx of MI
chest pains
elevated heart rate
palpitations
diaphoresis (excess sweat)
elevation in cardiac troponin
ST elevation? ECG abnormalities
GOT for HF
resolve fluid overload (0.5kg weight loss/day)
optimise HF therapy to prevent complications and reduce mortality risk
improve exercise capacity
when increasing furosemide for fluid overload episode, how much to increase?
double home dose or switch to IV (of same dose)
BD dosing for diuretic should not be at night to_
prevent need for pt to wake up at night to pee
always start with IV for episodes of fluid overload requiring hospitalisation at how much dose?
at same IV dose
what do beta blockers do
decrease HR and cardiac output
if patient is hemodynamically unstable, what to do with F4 agents
continue but maintain same dose
when to hold off SGLT2i
before surgery, in acute illness. not for fluid overload
what are the agents for HF
spironolactone
sglt28
arni/acei
bb
+
diuretic
first line for ascites
spironolactone, furosemide
when to hold use of bb
HR low
non pharm of HF
lose weight
restrict Na (<2g/d) and water (800-1L)
remove K from veg
weigh daily to monitor for fluid issues
cardiac rehab program and exercise
what to monitor for diuretic use
serum k, Na, Cr
genital infections
uses of f4 agents
- relieve/reduce sx
- reduce need for admissions
- prolong survival
GOT of ascites with liver cirrhosis
- managing sx and normalising liver abnormalities
- slowing down disease progression
- preventing complications of liver cirrhosis
GOT of viral hep B
viral suppression
GOT of hep C
viral eradication
what to do before treating hep b
screen for hiv
main side effect of concern for arni/acei
hypotension
bb for HF
bisoprolol, carvedilol (but not selective), metoprolol XL
how to manage portal htn
propranolol, nadolol, carvedilol
endoscopic variceal ligation (EVL)
nonpharm of ascites/cirrhosis
- drain out ascitic fluid
- abstain from alcohol
- salt restriction
- avoid nsaid, acei
*fluid restriction not necessary unless serum Na ≤125mmol/L
non pharm hepatitis b
- prevent disease transmission (household contacts shd b vaccinated)
- do not donate blood
- weight loss
- avoid alcohol and smoking
- inform healthcare providers of the condition
spironolactone se
gynaecomastia, hyperK
how to monitor asthma control
ACT questionnaire
why can’t use saba alone
increased risk of exacerbations and hospitalisation
downregulates beta receptors in lungs, reduce responsiveness, affect long term control
administration technique for ics-laba
use everyday even if well controlled
wash mouth after using to prevent oral thrush
non pharm for asthma / copd
- avoid triggers eg tobacco, allergens
- exercise/breathing exercises
- avoid use of nsaids, bb
- update vaccinations
- remediation of dampness or mould in homes
- dealing with emotional stress
- (copd) nutritional support
what is pulmonary rehab prog for copd
patient education, exercise trng, nutritional support, psychosocial support
vaccination in copd
pneumococcal: PCV13 and PPSV23
influenza
how to monitor asthma
symptoms of exacerbation, frequency of exacerbation and use of inhaler
what to always monitor fo HTN drugs
serum creatinine
benefit for sglt2i and loops used together
natriuresis effect - kidneys excrete sodium
how does liver cirrhosis affect drug distribution
decreased albumin pdtn. affects protein binding and amt of unbound drug
how does liver cirrhosis affect cyp enzyme
cyp expression reduced, decreased metabolism of drug, longer half life /elimination of drug
what is formula of hepatic extraction ratio
E = 1-F
what happens to drug when reduced hepatic blood flow
less drug brought to liver for metabolism, decreased clearance
high extraction ratio
> 0.7
when drug has high extraction ratio, is it perfusion limited? is it sensitive to changes in perfusion or protein binding?
yes. perfusion
when drug has low extraction ratio, is it perfusion limited? is it sensitive to changes in perfusion or protein binding?
no, protein binding
in cirrhosis, for drugs of high extraction ratio, do you have to reduce initial/maintenance dose?
yes both. affected greatly by extent of metabolism of liver. first past effect evident
maximal plasma concentration and F is increased, elimination is slowed.
in cirrhosis, for drugs of low extraction ratio, do you have to reduce initial/maintenance dose?
only maintenance dose. only elimination is slowed
what do drugs in bile undergo (2 ways)
1) enterohepatic cycling -reabsorption
2) excreted via feces
characteristics of drugs secreted into bile
- polar
- MW > 350g/mol
main side effect of statins
hepatic enzymes elevation, myalgia
estrogen metabolism
liver
obesity: serum albumin?
same