abx (anti-fungal)

Question 1

amphotericin b adverse effects

Answer 1

nephrotoxicity (hydrate adequately)
electrolyte imbalances, hypotension
thrombophlebitis
bone marrow suppression

Question 2

is ampho b safe in pregnancy

Answer 2

yes

Question 3

ampho b admin

Answer 3

iv/topical

Question 4

5fc can be used alone?

Answer 4

no, usually with amp b

Question 5

5fc SE

Answer 5

gi, bone marrow supprex, hepatotoxicity

Question 6

echinocandins activity

Answer 6

Aspergillus
and most Candida species, including those species resistant
to azoles.

Question 7

echinocandins pk

Answer 7

extensive protein binding (>97%) and are unable to
penetrate into CSF.

IV only

Question 8

triazoles AE

Answer 8

nausea,
vomiting,
headache,
and skin
rashes.

Hepatotoxicity
QT
prolongation

Question 9

azole hepatic metabolism

Answer 9

cyp450 3a4 inhbitor

Question 10

azole pregnancy ok?

Answer 10

teratogenic