Clozapine Flashcards
What is Clozapine primarily used to treat?
Clozapine is primarily used to treat treatment-resistant schizophrenia.
True or False: Clozapine is a first-line treatment for schizophrenia.
False.
What type of receptor does Clozapine predominantly act on?
Clozapine predominantly acts on dopamine D2 receptors.
Fill in the blank: Clozapine is an atypical _____ agent.
antipsychotic.
What is a major adverse effect of Clozapine?
A major adverse effect of Clozapine is agranulocytosis.
True or False: Clozapine can cause seizures.
True.
Which physiological effect is associated with Clozapine use?
Clozapine can cause sedation.
What should be monitored regularly in patients taking Clozapine?
White blood cell counts should be monitored regularly.
What is the mechanism of action of Clozapine?
Clozapine works by blocking multiple neurotransmitter receptors, including serotonin and dopamine receptors.
Multiple Choice: Which of the following is NOT an adverse effect of Clozapine? A) Weight gain B) Agranulocytosis C) Hyperactivity D) Seizures
C) Hyperactivity.
Fill in the blank: Clozapine has a higher risk of _____ compared to other antipsychotics.
metabolic syndrome.
What type of drug interaction can occur with Clozapine?
Clozapine can interact with medications that affect CYP450 enzymes.
True or False: Clozapine has a low risk of extrapyramidal symptoms.
True.
What is the relationship between Clozapine and hypersalivation?
Clozapine can cause hypersalivation as a side effect.
Which receptor types does Clozapine antagonize besides dopamine?
Clozapine also antagonizes serotonin 5-HT2A and 5-HT2C receptors.
True or False: Clozapine can be used in patients with a history of agranulocytosis.
False.
What is a common metabolic adverse effect of Clozapine?
Weight gain is a common metabolic adverse effect of Clozapine.
Fill in the blank: Clozapine is contraindicated in patients with a history of _____.
bone marrow suppression.
What is the risk of myocarditis associated with Clozapine?
Clozapine carries a risk of myocarditis and cardiomyopathy.
Multiple Choice: Which of the following is a serious side effect of Clozapine? A) Drowsiness B) Agranulocytosis C) Nausea D) Headache
B) Agranulocytosis.
What should patients be educated about when starting Clozapine?
Patients should be educated about the risk of agranulocytosis and the need for regular blood tests.
Fill in the blank: Clozapine can lead to increased risk of _____ due to metabolic changes.
diabetes.
True or False: Clozapine can be used safely with other antipsychotics.
False.
What is the importance of titration when prescribing Clozapine?
Titration is important to minimize the risk of seizures and other side effects.
