Clotting factors Flashcards
What are the clotting factors that are found outside the liver?
III (3)
IV (4)
XII (12)
XIII (13)
Clotting factor 1 Name and Origin…
Fibrinogen, Liver
Clotting factor 2 Name and Origin…
Prothrombin, Liver
Clotting factor 3 Name and Origin…
Tissue factor thromboplastin, Perivascular tissue
Clotting factor 4 Name and Origin…
Calcium, Plasma
Clotting factor 5 Name and Origin…
Proaccelerin (Labile factor), Liver
Clotting factor 7 Name and Origin…
Proconvertin (stable factor)
Clotting factor 8 Name and Origin…
“Antihemophilic factor A” or “Antihemopilic globulin”, Liver
Clotting factor 9 Name and Origin…
“Antihemophilic factor B” or “Christmas factor”, Liver
Clotting factor 10 Name and Origin…
Stuart-Prower factor, liver
Clotting factor 11 Name and Origin…
Name associated disease…
“Plasma Thromboplastin antecedent”, Liver
associated with Hemophilia C, and Rosenthal syndrome
Clotting factor 12 Name and Origin…
Hageman factor
Liver, Platelets
Clotting factor 13 Name and Origin…
Fibrin Stabilizing factor, or Lake-lorand factor
Platelets, plasma
Extrinsic Mechanism basic steps
Damage to Perivascular tissue»>
Thromboplastin (Factor 3)»>
Factor 7»>
Intrinsic pathway basic steps
Platelets>>> Factor 12>>> Factor 11>>> Factor 9>>> Factor 8>>>
Common Pathway Mechanism Basic steps
Factor 10>>> Prothrombin activator>>> Prothrombin (Factor 2)>>> Thrombin>>> Fibrinogen (Factor 1)>>> Fibrin>>> Fibrin Polymer (clot)
Extra factors involved with the Extrinsic pathway
Ca2+ and Factor V involved
Extra factors involved with the intrinsic pathway
Ca2+, and PF3 involved
Extra factors involved with the common pathway
Factor 3 Factor 4 Ca2+ (involved 2 times) PF3 Factor 13
Vitamin K dependent clothing factors
2, 7, 9, and 10