Clotting Cascade ch 4

Question 1

Factors involved in the contact activation/intrinsic pathway

Answer 1

XII, XI, IX, (VIII),X

Extrinsic and intrinsic pathways converge on factor X

Question 2

Factors involved in the extrinsic pathway

Answer 2

Tissue factor = factor VII, X

Extrinsic and intrinsic pathways converge on factor X

Question 3

Factors involved in the final common pathway

Answer 3

Begins with factor X

II (prothrombin), I = fibrin

Factor XIII helps formation of a cross-linked fibrin clot

Question 4

Vitamin K dependent clotting factors

Answer 4

II, VII, IX and X

Question 5

Which 3 factors contribute to thrombus formation (Vichows triad)?

Answer 5

1. Endothelial damage
2. Hypercoaguability
3. Stasis or turbulent blood flow