Clostridum Difficile Flashcards by T Z | Brainscape

Q

C. difficile

A

normal gut flora suppressed by use of antibiotics

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Q

causes

A

cephalosporins

clindamycin

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Q

signs

A

diarrhoea
vomiting
abdo pain
unwell

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Q

investigations

A

presence of toxin in stool

stool antigen test - previous infection

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Q

criteria

A

mild:
normal WCC

moderate:
raised WCC

severe:
raised creatinine
fever

life threatening:
megacolon
hypotension

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Q

management

A

1st line:
oral vancomycin for 10 days

2nd line:
oral fidoxamicin

3rd line:
IV vancomycine + metronidazole

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Q

management of relapse

A

within 12 weeks:
oral fidoxamicin

post 12 weeks:
oral vancomycin or fidoxamicin

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Q

what is given in life threatening C. difficile

A

oral vancomycin and metronidazole

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