Clostridium Difficile Flashcards
1
Q
Describe the appearance of clostridium difficile under the microscope
A
Gram positive - purple
Rod shaped
2
Q
What are the virulence factors of clostridium difficile?
A
Produces cytotoxins - destroy cell membranes
Produces enterotoxins - causes excess fluid loss from intestines and inflammatory response
3
Q
What does clostridium difficile cause?
A
Loose stools
Severity up to pseudomembranous colitis
4
Q
What causes clostridium difficle infection?
A
Use of antibiotics, kills normal intestinal flora allowing c.diff to grow
Contamination of environment with c.diff spores
5
Q
What antibiotics induce c.diff infection?
A
Amoxicillin
Ampicillin
Cephalosporins
6
Q
How is a c.diff infection treated?
A
Vancomycin
Fluid replacement
