Clostridium Flashcards
Module 4
Causative agent of Tetanus
Clostridium tetani
Morphology of Clostridium
Straight, slender rod shaped (Gram variable)
True or False,
Clostridium does not ferment Carbohydrates
True
3 toxins produced by Clostridium tetani
- Tetanospasmin
- Tetanolysin
- Peripherally active non-spasmogenic toxin
What toxin produced by Clostridium tetani is responsible for characteristic feature of tetanus
Tetanospasmin
What toxin produced by Clostridium tetani is responsible for local tissue necrosis favorable for multiplication
Tetanolysin
Travel route of Tetanospasmin
Nerve trunk to Spinal Cord
Tetanospasmin inhibits the release of ________ which is a transmitter substance responsible for inhibitory nerve network of spinal cord
Glycine
Portals of entry of Clostridium tetani
- Nail wounds in horses
- Castration
- Calving, dehorning, nose ringing (Cattle)
- Autointoxication
- Umbilical Cord in Newborns
This toxin produced by Clostridium tetani has a paralytic action on PNS and inactivation of inhibitory nerve network
Tetanospasmin
This species of Clostridium is a source of potent neurotoxin characterized by Flaccid Paralysis
Clostridium botulinum
Morphology of Clostridium botulinum
Oval spores, centric and eccentric
Major Metabolic End product of all strains
Acetic Acid
This toxin consists of hemagglutinin moiety
Botulism toxin
True or False,
Botulism toxin is released during lysis of cell
True