Bacillus Flashcards
Module 3
Most pathogenic species of the Genus Bacillus
Bacillus Anthracis
Morphology of Bacillus
Large rod shaped, Gram positive
(Bacillus anthracis forms long chains in cultures with square ends)
Major anthrax enzootic zones
India, Pakistan, Africa, South America, Philippines
What is the component of capsule of Bacillus
Polymers of D-glutamic acid and some polysaccharide
What are the toxin complex or holotoxin
- Edema Factor
- Protective Antigen
- Lethal Factor
Net effect of Holotoxin
- Kills phagocytes
- Increase capillary cell permeability
- Damage clotting mechanism
- Inhibit bactericidal activity of Serum
Forms of Anthrax
- Localized
- Generalized
What form of anthrax is a wound on skin, cutaneous, malignant carbuncle or pustule
Localized Anthrax
This form of anthrax is an airborne spore; woolsorter’s disease
Generalized Anthrax
Symptoms of Anthrax
Edema, Shock, Hemorrhage before death
This diagnosis stains the organism blue and capsules pink
McFadyean’s stain
This diagnosis detects capsular antigen
Agar Gel Precipitation Test
This diagnosis results to a Medusa-Head or judge wig type
Ground glass-like non-hemolytic colonies on Blood Agar Plate
Organisms grow with cell wall impairment due to
Presence of Penicillin
What bacteriophage can Lyse B. anthracis
Gamma phage