Clopidogrel (Plavix)

Question 1

• Therapeutic Classification

Answer 1

anti-platelet agent

Question 2

• Pharmacologic Classification

Answer 2

ADP receptor blocker

Question 3

• Pregnancy Category

Answer 3

B

Question 4

• Mechanism of Action

Answer 4

o Inhibits ADP receptors on platelets and prolongs bleeding time by irreversibly inhibiting platelet aggregation

Question 5

• Indications

Answer 5

o Reduce risk of CVA/MI
o Reducing thrombolytic events post CVA/MI
o Prevent DVT
o Prevent Thrombi formation unstable angina/coronary stents

Question 6

• Contraindictions:

Answer 6

Active Bleeding

Question 7

Precautions

Answer 7

o High risk of bleeding

o Severe hepatic disease

Question 8

• Drug Interactions

Answer 8

o Increased risk of bleeding with anticoags, antiplatelets, thrombolytic agents and NSAIDs
o Diminished antiplatelet actions with drugs that inhibit hepatic metabolic enzymes
o Increased anticoagulant activity with drugs that increase hepatic metabolic enzymes

Question 9

• Adverse Effects

Answer 9

o	Flu like syndrome
o	Headache
o	Diarrhea
o	Bruising URTI
o	Rash
o	Pruritis

Question 10

• Serious Adverse Effects

Answer 10

abnormal bleeding

Question 11

• Nursing Responsibilities

Answer 11

o Assess current use of anticoags and NSAIDs
o Assess for increased bleeding risk
o Monitor for bleeding
o Evaluate unexplained fever/infection

Question 12

• Patient/Family Teaching

Answer 12

o Immediately report unusual bleeding
o Know it may take longer to stop bleeding
o Do not stop taking drug
o Do not use NSAIDs other OTC meds, herbal supps
o Inform dentist and other care providers prior to procedure