Clinicometrics Flashcards
crude mortality
total # of deaths in a population / entire population
cause specific mortality
deaths from disease / entire population
case fatality mortality
deaths from disease / # of cases of disease
proportionate mortality for disease
deaths from disease / total # deaths in a population
prevalence
total number of cases in a population at a given time
cases at time T / population at time T
does NOT determine risk or probability of becoming a case
what type of study determines prevalence
cross sectional studies
can CS studies calculate risk/probability
no because it ignores disease duration
what factors influence prevalence
- population dynamics
- duration of disease
prevalence = incidence x disease duration
incidence
risk/probability of disease occurring in a time period
used to compare disease occurrence in one group versus another (exposed vs not exposed OR treatment vs controls)
what type of study determines incidence
clinical trials
cohort studies
what is required in order to calculate incidence
defined time interval (study length)
incidence proportion
new cases during study period / susceptible subjects
ranges from 0 to 1
assumes subjects do not have disease at the start of the time period and are not at risk of being removed from the population
limitations of calculating incidence proportion
- diseases with recurrence
- dynamic populations - requires calculation of incidence rate
incidence rate
new cases during study period / time that subjects are at risk of disease
denominator = sum of time at risk for all individuals in the population
- accounts for dynamic populations
measured in units of time (cases per X number of days)
2X2 tables - A, B, C, D
A: diseased + exposed
B: diseased + not exposed
C: healthy + exposed
D: healthy + not exposed
risk ratio (RR)
incidence proportion in exposed / incidence proportion in unexposed
relative risk, incidence proportion ratio
(# exposed new cases / total # exposed) / (# unexposed new cases / total # unexposed)
=
(A / A+C) / (B / B+D)
how do you interpret risk ratio
RR probability of developing disease in exposed vs unexposed
range of risk ratio
0 to infinity
RR > 1: exposure is a risk factor for disease
RR < 1: exposure is protective against disease
risk difference
incidence proportion in exposed - incidence proportion in unexposed
(A/ A+C) = (B/ B+D)
absolute measure of risk
determines the importance of the disease
interpretation of risk difference
for every (total # exposed), only X develop disease due to exposure
incidence rate ratio
incidence rate in exposed/ incidence rate in unexposed
(# exposed new cases / time exposed are at risk) / (# unexposed new cases / time unexposed are at risk)
interpretation of incidence rate ratio
patients will get disease IRR times faster if exposed
hazard rates
similar to incidence rate but estimated from a type of statistical model that estimates time to event of interest in different groups
cohort study uses
good for COMMON diseases to calculate RISK RATIO
start with population at risk (disease free) –> determine exposure