CLINICAL TRIALS OF DEPRESSION

Question 1

What are the newer targets outside the monoamine hypothesis?

Answer 1

• Glutaminergic & NMDA receptor modulators
• GABA A receptor positive modulators
• K-opioid receptors
• Nicotinic receptors
• Nociceptor receptors

Question 2

Why is it difficult to have trials

Answer 2

unclear biological drug target

different possible populations to assess

• no surrogate marker
• difficult to balance between comprehensive long-term follow up and managing drop-out rates