Clinical Skills Flashcards
What findings should you look for in an examination of a local swelling?
Site.
Size.
Definition - well- or ill-defined.
Consistency - cystic, solid, soft, hard.
Surface - smooth, regular.
Mobility or fixity - to skin or deep tissues.
Temperature - abscess.
Transilluminable - fluid-filled.
Overlying skin changes.
Local lymphadenopathy.
What is the relevance of testing haemoglobin in rheumatology?
May be low in most inflammatory conditions - may be an indicator of disease activity.
May get iron deficiency anaemia with NSAIDs.
What is the relevance of testing MCV in rheumatology?
May be high in patients on sulfasalazine, methotrexate, or azathioprine - this is of no significance if the Hb is stable and B12, folate and TFTs are normal.
Low in iron deficiency.
What is the relevance of testing neutrophil in rheumatology?
May be low in connective tissue diseases (especially SLE and Sjogren’s syndrome).
Neutropenia can be an adverse effect of most DMARDs.
Occasionally can be raised in inflammatory arthritis.
What is the relevance of testing lymphocyte count in rheumatology?
May be low in connective tissue disease (especially SLE and Sjogren’s syndrome) - indicator of disease activity.
Reduced by immunosuppressants.
What is the relevance of testing platelet count in rheumatology?
May be low in connective tissue diseases (especially SLE, Sjogren’s syndrome and antiphospholipid syndrome).
What is the relevance of testing plasma viscosity in rheumatology?
High in inflammatory conditions - indicator of disease activity.
What is the relevance of testing renal markers in rheumatology?
Methotrexate is excreted renally, therefore, risk of toxicity if there is renal impairment.
Connective tissue disease may cause renal impairment.
What is the relevance of testing liver function in rheumatology?
DMARDs, allopurinol and NSAIDs may cause hepatitis.
What is the relevance of testing corrected calcium in rheumatology?
Hyperparathyroidism may cause pseudogout/calcium pyrophosphate arthropathy (CPPD).
What is the relevance of testing ferritin in rheumatology?
Low in iron deficiency, high in anaemia of chronic disease - even in presences of iron deficiency can be artificially high in inflammatory disease as it also acts as an acute phase reactant.
What is the relevance of testing creatine kinase in rheumatology?
Raised in myositis - indicator of disease activity; may also be raised in muscle trauma and strenuous exercise.
What is the relevance of testing uric acid in rheumatology?
Raised in gout - normal in about 30% of cases of acute gout; may get asymptomatic hyperuricaemia.
What is the relevance of testing urine protein/creatinine ratio in rheumatology?
May get glomerulonephritis as part of connective tissue disease/vasculitis.
What is the relevance of synovial fluid microscopy and culture in rheumatology?
If suspected septic arthritis or crystal arthritis.
What is the relevance of testing rheumatoid factor in rheumatology?
70% sensitive (only 50% in early arthritis), 85% specific for rheumatoid arthritis.
Extra-articular manifestations of RA very unlikely, if RF is negative.
Worse prognosis in sero-positive patients.
What are the extractable nuclear antigens (ENA)?
Anti-RNP.
Anti-centromere antibody.
Anti-Scl-70.
Anti-Ro; anti-La.
Anti-Jo-1.
Anti-SM.
Anti-cardiolipin (ACLA) antibodies.
What is the relevance of testing anti-CCP antibody in rheumatology?
70% sensitive.
~98% specific for RA.
Worse prognosis in sero-positive patients.
What is the relevance of testing anti-nuclear antibody in rheumatology?
98% sensitive for SLE (hence negative test is very useful to rule out SLE) but very non-specific e.g. 13% adults are positive at a titre of 1/80.
Positive in a wide range of connective tissue diseases including RA.
What is the relevance of testing anti-dsDNA antibody in rheumatology?
95% specific for SLE, positive in about 30% - may fluctuate with disease activity and can be used to monitor disease activity.
What is the relevance of testing anti-RNP antibody in rheumatology?
Usually positive in mixed connective tissue disease and may be positive in SLE.
What is the relevance of testing anti-centromere antibody in rheumatology?
Usually positive in limited systemic sclerosis.
What is the relevance of testing anti-Scl-70 antibody in rheumatology?
May be positive in diffuse systemic sclerosis.
What is the relevance of testing anti-Ro and anti-La antibody in rheumatology?
Usually positive in diffuse systemic sclerosis.
What is the relevance of testing anti-Jo-1 antibody in rheumatology?
May be present in inflammatory myositis.
What is the relevance of testing anti-Sm antibody in rheumatology?
Very specific for lupus but in UK population only positive in ~3%.