Clinical Pharmacology Exam II

Question 1

In general, hepatobiliary therapeutics include ____, ____, and _____ treatments,

Answer 1

Question 2

What are some common goals for symptomatic therapy of hepatobiliary diseases?

Answer 2

Question 3

List some of the different gastroprotectants we use as a supportive treatment for patients with hepatobiliary disease.

Answer 3

Question 4

List some of the different appetite stimulants we use as a supportive treatment for patients with hepatobiliary disease.

Answer 4

Question 5

List some of the different antiemetics we use as a supportive treatment for patients with hepatobiliary disease.

Answer 5

Question 6

How do we detoxify or remove intestinal toxins to decrease the symptoms of HE?

Answer 6

Question 7

What are some drugs we use to control seizure management in our patients with HE?

Answer 7

Question 8

How do we manage ascites in our patients with hepatobiliary disease?

Answer 8

Question 9

How do we manage coagulopathies in our patients with hepatobiliary disease?

Answer 9

Question 10

What are the primary goals of our systemic and hepatobiliary specific treatments for patients with hepatic disease?

Answer 10

Question 11

Briefly describe how we modify anesthesia for patients with liver disease.

Answer 11

Question 12

How do we modify fluid therapy for patients with ascites?

Answer 12

Question 13

How do we modify fluid therapy for patients with hepatic insufficiency/PSS?

Answer 13

Question 14

How do we modify fluid therapy for patients with hepatic failure?

Answer 14

Question 15

How do we modify fluid therapy for patients with hepatic lipidosis?

Answer 15

Question 16

How do we modify fluid therapy for patients with hepatic encephalopathy?

Answer 16

Question 17

Why do we tend to reach for colloid fluids in our patients with hepatic disease?

Answer 17

Question 18

List some of the different antioxidants we use in our patients with hepatitis disease.

Answer 18

Question 19

List some of the different water soluble vitamins we use in our patients with hepatitis disease.

Answer 19

Question 20

List some of the different fat soluble vitamins we use in our patients with hepatitis disease.

Answer 20

Question 21

Briefly describe the role and complexity of the hepatic antioxidant system.

Answer 21

Question 22

Describe the roles that thiols play in the hepatic antioxidant system.

Answer 22

Question 23

Why do we want to support hepatic GSH in patients with liver disease?

Answer 23

Question 24

Describe NAC as an antioxidant that we supplement in patients with liver disease.

Answer 24

Question 25

Describe SAMe as an antioxidant that we supplement in patients with liver disease.

Answer 25

Question 26

What are the 4 core effects of ursodiol?

Answer 26

Question 27

What are the uses and side effects of ursodiol?

Answer 27

Question 28

What are some of the different antifibrotic agents we user in our patients with hepatic disease?

Answer 28

Question 29

What is the mechanism of action of colchicine?

Answer 29

Question 30

What are the indications for colchicine? What are the side effects?

Answer 30

Question 31

Describe the use of polyunsaturated phosphatidylcholine in patients with hepatic disease.

Answer 31

Question 32

Describe the use of milk thistle in patients with hepatic disease.

Answer 32

Question 33

What are the different anti-inflammatory drugs we may use in patients with hepatobiliary disease?

Answer 33

Question 34

Advantageous combination therapy in necroinflammatory and cholestatic liver disorders may include _____, other _____ or _____ prescription drugs combined with various _____.

Answer 34

Question 35

Adjunctive therapy with an effective ____ and ____ may optimize control of inflammatory mediator release and cell response as compared to pure immunomodulatory treatment or therapy limited to antioxidants.

Answer 35

Question 36

Describe the use of antibiotics in patients with hepatobiliary disease.

Answer 36

Question 37

List the different immunosuppressant drugs we use in our patients with hepatobiliary disease.

Answer 37

Question 38

List some of the different drugs we use in patterns with copper hepatopathy.

Answer 38

Question 39

What are the different effects of zinc?

Answer 39

Question 40

When should we consider supplementing zinc in our patients with hepatobiliary disease? What are the side effects?

Question 41

Name and describe the different copper chelating drugs we use in patients with copper hepatopathy.

Answer 41

Question 42

Describe your fluid therapy plan for a cat with hepatic lipidosis.

Answer 42

Question 43

Describe your nutritional support plan for a cat with hepatic lipidosis.

Answer 43

Question 44

List some of the different adjuvant therapies you would use in a cat with hepatic lipidosis.

Answer 44

Question 45

Lay out an appropriate treatment plan for feline cholangiohepatitis.

Answer 45

Question 46

Lay out an appropriate treatment plan for feline neutrophilic CCHS.

Answer 46

Question 47

Lay out an appropriate treatment plan for feline non-neutrophilic CCHS.

Answer 47

Question 48

What are our goals when treating canine chronic hepatitis?

Answer 48

Question 49

Lay out a comprehensive treatment plan for canine chronic hepatitis.

Answer 49