Clinical Neurophysiology Flashcards

1
Q

What is clinical neurophysiology

A

medical specialty that studies the central and peripheral nervous systems through the recording of bioelectrical activity, whether spontaneous or stimulated.

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2
Q

What does an EMG investigate

A

To investigate problems of peripheral nerve and muscle

and

Investigate the function of the neuromuscular junction

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3
Q

What does nerve conduction studies ( + EMG) investigate

A

To investigate problems of peripheral nerve and muscle

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4
Q

What does EEG investigate in clinical neurophysiology

A

Electrical activity within the brain to investigate epilepsy and states of altered consciousness

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5
Q

What does evoked potential investigate in clinical neurophysiology

A

Visual and somatosensory, investigate problems in central pathways

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6
Q

In nerve conduction studies how do you examine if the nerve is functioning

A

By testing
Conduction velocity
and Amplitude

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7
Q

How does nerve conduction study work

A

During the test, the nerve is stimulated, usually with surface electrode patches attached to the skin

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8
Q

How do you test the velocity of conduction in nerve conduction studies

A

Measure distance and time between the onset of the two action potentials

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9
Q

how do test the amplitude in nerve conduction studies

A

Increase strength to they and stimulate more nerves

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10
Q

What is usually combined with nerve conduction studies

A

Electromyography

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11
Q

Define electromyography

A

Needle measures the AP at the top and the core, looking at the action potential from the whole motor unit

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12
Q

How do you measure sensory function separately to motor function in neurophysiology

A

Similar technique but stimulating the sensory nerve fibres in the fingers

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13
Q

What is the electrophysiology findings of a neuropathy in nerve conduction studies

A

Slowing of motor response where conduction block is located

small sensory response

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14
Q

What is the electrophysiology findings of a radiculopathy in nerve neurophysiology

A

Small but slowed motor response

Normal sensory response

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15
Q

How is sensory response normal in radiculopathy

A

If the signal is damaged at the nerve root the sensory signal remain intact as sensory cell body lives in dorsal root ganglion so patients sensory nerve can still be stimulated even though patient feels numbness

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16
Q

How do you reach a full diagnosis in nerve neurophysiology

A

Investigate nerve function with anatomy allows diagnosis of nerve entrapment

17
Q

What is the pathology of myasthenia gravis

A

Autoimmune antibodies to post-synaptic ACh receptor, decreasing the effectiveness of released ACh

18
Q

What is the clinical presentation of myastheniagravis

A

Weakness (can be generalised)

Fatigue

Normal sensation

Ptosis

Diplopia

19
Q

How do you diagnose myastheniagravis

A

Detect antibodies

Neurophysiology:

  • repetitive stimulation
  • single fibre EMG
20
Q

How does EMG manage to look at action potential from whole motor units

A

uses filter, sensitivity and timebase settings to isolate the action potentials from individual muscle fibres within one motor unit.

21
Q

Where are EMGs useful

A

Needle can be positioned to record from two fibres within the same motor unit

(Normally little variation in time of firing between two such fibres)

22
Q

What can EMG diagnose

A

diagnose neuromuscular abnormalities eg myasthenia, botulism

23
Q

In a neuromuscular disease when relationship at the NMJ is lost how does an EMG diagnose this

A

Jitter

24
Q

How does EEG diagnose worse myasthenia

A

There is block in signal

25
Q

How does an EEG asses brain function

A

Recording electrical activity generated by cortical neurons across multiple points on the scalp

26
Q

What can be seen in an EEG

A

Epileptic Activity

States of consciousness
(Sleep, stages of sleep)

Encephalopathy

27
Q

Looking at brain function in an EEG allows you to diagnose

A

Epilepsy

Altered states of consciousness

  • sleep disorders
  • changes in sleep

Non-epileptic attacks

Facilitate medical or surgical treatment for epilepsy