Blackouts, First seizures and Epilepsy Flashcards

1
Q

What is the 9 different causes of a black out

A

Syncope

First seizure

Hypoxic seizure

Concussive seizure (after blow to head)

Cardiac arrhythmia

Non-epileptic attack

Narcolepsy,

Movement disorder,

Migraine

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2
Q

What is the commonest cause of fainting/syncope

A

Vasovagal syncope:

When you faint because your body overreacts to certain triggers, such as the sight of blood or extreme emotional distress causing your heart rate and blood pressure to drop suddenly

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3
Q

What is the features of syncope

A

Happens in the upright position

Pallor common

Gradual onset

Rapid recovery

Incontinence rare

Precipitants common

Injury rare

Early symptoms:
Light-headed, Nausea
Hot, sweating
Tinnitus
Tunnel vision
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4
Q

Why is injury rare in syncope and common in seizure

A

Due to gradual onset, patients can get themselves into a safe position avoiding injury, where in a seizure there is no warning do injury is more common

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5
Q

What is the features of seizures

A
Occur in any posture
Pallor uncommon
Sudden onset
Injury quite common
Incontinence common
Slow recovery
Precipitants rare
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6
Q

What occurs in hypoxic seizures

A

Continued oxygen deprivation, e.g. when individual kept upright in a faint

Patient has succession of collapses

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7
Q

What is an example of a cardiac arrhythmia that can cause seizure

A

Long QT syndrome

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8
Q

When would long QT syndrome result in a seizure

A

Collapse occurs with exercise

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9
Q

When should you consider cardiac arrhythmias as the cause of seizures

A

When there is a family history of sudden death,

When there is a cardiac history

When collapse occurs with exercise

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10
Q

What can seizures cause over time

A

Cardiac arrhythmias

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11
Q

What is common features of non-epileptic attacks

A

Commoner in women than men

Can be frequent

May look bizarre

Can be prolonged

May have a history of other medically unexplained symptoms

May have history of abuse

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12
Q

What does a non-epileptic attack look like

A

May superficially resemble a generalised tonic-clonic seizure (rigid with jerking)

May resemble a “swoon”- flat on the ground and pale

May involve bizarre movements (thrusting of hips - sexual abuse)

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13
Q

What investigations must take place at a possible first seizure

A

Blood sugar - rule out as cause of blackout

ECG - what kind of seizure

Consideration of alcohol and drugs

CT head - see structural problems

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14
Q

After diagnosing a first seizure what needs to be discussed with the patient

A

Enquire about employment and dangerous leisure actuates

Explain driving regulations

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15
Q

What is the driving regulations put in place after a patient has their first seizure

A

Patient may drive a car after 6 months if their investigations are normal and they have had no further events

They may drive an Heavy good vehicle or Public Service Vehicle after 5 years if their investigations are normal, they have no further events and they are not on anti-epileptic medication

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16
Q

After first seizure, when would an epilepsy diagnosis be made

A

After a second unprovoked attack

Sometimes on taking the history after a first seizure, it is clear that they have undiagnosed epilepsy

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17
Q

What features in your history suggest undiagnosed primary generalised epilepsy

A

History of myoclonic jerks, especially first thing in the morning

Absences or feeling strange with flickering lights

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18
Q

What is features in your history suggesting a focal onset epilepsy

A

History of “deja vu”, rising sensation from abdomen,
Episodes where look blank with lip-smacking,
Fiddling with clothes

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19
Q

Define an epileptic seizure

A

Epileptic seizure is an intermittent stereotyped disturbance of consciousness, behaviour, emotion, motor function or sensation which, on clinical grounds, is believed to result from abnormal neuronal discharges

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20
Q

Define epilepsy

A

condition in which seizures recur, usually spontaneously

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21
Q

Where does damage occur in an epileptic seizure

A

Grey matter

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22
Q

What is the two ILAE Classifications of epilepsy

A

Generalsed seizures

Focal seizures

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23
Q

What are the 6 different types of generalise seizures

A

Tonic-clonic seizures

Myoclonic seizures

Clonic seizures

Tonic seizures

Atonic seizures

Absence seizures

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24
Q

What occurs in a tonic-clonic seizure

A

Usually begins on both sides of the brain, but can start in one side and spread to the whole brain.

A person loses consciousness, body become rigid (tonic) , and jerking movements (clonic) are seen

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25
What occurs in a myotonic seizure
Brief shock - like jerks of a muscles and the person is usually awake and able to think clearly
26
What is seen in a tonic seizure
Produce constant contractions of the muscles. The person may turn blue if breathing is impaired
27
What is seen in a clonic seizure
involve shaking of the limbs in unison
28
What is seen in an absence seizure
Non convulsive seizure Can be subtle, with only a slight turn of the head or eye blinking. Lasting only a few seconds The person often does not fall over and may return to normal right after the seizure ends
29
What is focal seizures characterised by
According to aura: Motor features, Autonomic features Degree of awareness or responsiveness
30
What can focal seizures progress to
Generalised convulsive seizures
31
What can focal seizures be divided into
Simple e.g. hand jerk and conscious Complex e.g. any disturbance to your conscious level (appear confused or dazed and can not respond to questions or direction)
32
What is the common presentation of primary generalised epilepsy
No warning Diagnosed <25 years History of absences and myoclonic jerks as generalised tonic-clonic seizure May have a family history Abnormal EEG
33
What is the common presentation of a focal epilepsy
May get an “aura” Any age – cause can be any focal brain abnormality Simple partial and complex partial seizures can become secondarily generalised Focal abnormality on EEG MRI may show cause
34
What investigation can show the cause of a focal epilespy
MRI
35
What occurs in primary generalised epilepsy
Occurs in both hemispheres | due to disorder of brain function causing a group of neurones to fire in an abnormal, excessive, and synchronized manner
36
What is a common pathological cause of generalised epilepsy
Channelopathies Inhibitory neurons not functioning properly so there is a constant firing of excretory neurone resulting in a wave of depolarisation across the brain
37
What occurs in focal onset epilepsy
Disorder of brain structure usually occurring in one hemisphere of the brain
38
Focal epilepsy is often preceded by certain experience known as auras, these include
Sensory, visual, psychic, autonomic, olfactory or motor phenomena with a degree of awareness or responsiveness
39
What are the investigation used for epilepsy
EEG MRI CT (exclude other causes) Video- telemetry
40
What further processes take place with an EEG to help diagnose epilepsy
Hyperventilation Photic stimulation Sleep deprivation - used to help trigger an primary generalised epileptic seizure
41
When is an MRI investigation used in epilepsy
For patients under age 50 with possible focal onset seizures
42
How and when would video-telemetry occur in epileptic investigations
If the diagnosis is uncertain Using EEG and ECG monitoring to see how long someone is have a seizure so can differentiate between no epileptic and epileptic
43
What is the first line treatment for primary generalised epilepsy
Sodium Valproate Lamotrigine Levetriacetam
44
What is the first line treatment for partial and secondary generalised seizures
Lamotrigine | Carbamazepine
45
What is the first line treatment for absence seizures
Ethosuximide
46
What is the second line treatment for generalised epilepsy
Topiramate Zonisamide (carbamazepine)
47
What is the second line treatment for partial seizures
- Sodium valproate - Topiramate - Leviteracetam - Gabapentin - Pregabilin - Zonisamide - Lacosamide - Perampanel - Benzodiazepines
48
What is the side effects of sodium valproate
tremor, weight gain, ataxia, nausea, drowsiness, transient hair loss, pancreatitis, hepatitis
49
Why is sodium valproate avoided during pregnancy
As can cause birth defects: Delayed language development Autism
50
What is the side effects of carbamazepine
Ataxia, drowsiness, nystagmus, blurred vision, low serum sodium levels, skin rash
51
What is the side effects of levetiracetam
Irritability | Depression
52
What is the side effects of topiramate
weight loss, word-finding difficulties, tingling hands and feet
53
What is the side effects of zonisamide
bowel upset, cognitive problems
54
What is the contradiction in carmazepine treatment
Makes myoclonic jerks worse
55
When can epileptic patients hold a group 1 licence
Once they have been seizure free for a year or have only had seizures arising from sleep for a year. If they have ever had a day time seizure but then the pattern becomes noctural, this must be established for three years before they can drive
56
When can epileptic patients hold a HGV and PSV licence
Have been seizure free for 10 years and are not on anti-epileptic medication
57
Define status epilepticus
Prolonged or recurrent tonic-clonic seizures persisting for more than 30 minutes with no recovery period between seizures
58
Status epilepticus usually occurs in patients with no previous history of epilepsy, so what is the potentially causes
Stroke Tumour Haemorrhage Intoxicants (alcohol, drugs)
59
Status epilepticus can be life threatening with out treatment so what is the first line treatment available
Midazolam: 10mg by buccal or intra-nasal route, repeated after 10mins if necessary Lorazepam: 0.07mg/kg, usually 4mg bolus repeated once after 10 mins Diazepam: 10 - 20mg iv or rectally, repeated after 15 mins if necessary
60
What is the second line treatment of Status epilepticus if first line treatment doesn't work
Phenytoin - slow infusion of 15 – 18mg/kg at 50mg/min Valproate – 20 -30mg/kg iv at 40mg/min Levetiracetam - IV (near status)
61
What is the third line treatment of status epilepticcus if it still isn't under control
Anaesthesia usually with propofol or thiopentone
62
What occurs in third line treatment of status epilepticcus
Shuts of brain activity, and leave for 24 hours, and administrate anticonvulsants
63
What is SUDEP
Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy, where brain activity just flat lines
64
What mechanisms are potential involved in SUDEP
Autonomic malfunction - Cardiac arrhythmias - Respiratory failure - Pulmonary dysfunction - Brain stem - apnea