Clinical Microbiology — SCT II [Vol. 1] Flashcards

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1
Q

Mention 5 diseases that are frequently caused by Staphylococcus aureus!

A
  1. Folliculitis
  2. Frunculus
  3. Bullous impetigo
  4. Osteomyelitis
  5. Food poisoning
  6. Pneumonia
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2
Q

Mention 2 toxin-mediated staphylococcal diseases!

A
  1. Toxic shock syndrome (TSS)
  2. Scalded skin syndrome
  3. Food poisoning
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3
Q

Mention 3 toxic products produced by Staphylococcus aureus

A
  1. TSST (Toxic shock syndrome toxin)
  2. Enterotoxin
  3. Exfoliatin
  4. Leukocidins
  5. Hemolysins
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4
Q

Which is the most virulent species of the Staphylococcus genus?

A

S. aureus

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5
Q

Which enzymatic virulence factor is characteristic exclusively for Staphylococcus aureus?

A

Exocoagulase

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6
Q

Which biochemical test can be used to differentiate staphyloccoci from streptococci?

A

Catalase test

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7
Q

Which antibacterial drug is the first choice in serious infections caused by methycillin sensitive Staphylococcus aureus (MSSA) strains?

A

Oxacillin (cloxacillin, flucloxacillin)

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8
Q

Which antibacterial drug is the first choice in serious infections caused by methycillin resistant Staphylococcus aureus (MRSA) strains?

A

Glycopeptides (vancomycin, teicoplanin)

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9
Q

In which diseases is Staphylococcus saprophyticus considered an obligate pathogen?

A

Cystitis in young women

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10
Q

Which cell constituents determine the group-specific, and the type specific antigens of Streptococcus pyogens, respectively?

A

Group specific: C-polysaccharide
Type specific: M protein

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11
Q

Mention 3 enzymes produced by Streptococcus pyogens that enhance the spread of the bacterial infection in the body!

A
  1. Streptokinase (fibrinolysin)
  2. Hyaluronidase
  3. Streptodornase (DNAse)
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12
Q

List 3 diseases caused by Streptococcus pyogens in the skin or in subcutaneous tissues!

A
  1. Impetigo
  2. Erysipelas
  3. Cellulitis
  4. Necrotizing fasciitis
  5. Myonecrosis
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13
Q

Mention a toxin-mediated streptococcal disease; specify the name of the toxin and its mechanism of action!

A
  1. Scarlet fever — erythrogenic toxin — superantigen causing capillary destruction
  2. Streptococcal toxic shock syndrome (TSS) - TSST - superantigen
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14
Q

Mention 2 poststreptococcal diseases!

A
  1. Glomerulonephritis
  2. Rheumatic fever
  3. Erythema nodosum
  4. Chorea minor
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15
Q

Which product of Streptococcus pyogens has a major pathogenic role in poststreptococcal diseases?

A

M protein: may induce hypersensitivity reactions

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16
Q

How long does immunity against scarlet fever exist? Which immune effector mechanism is involved?

A

Life-long immunity. Antitoxic antibodies are involved.

17
Q

What is the drug of first choice in Streptococcus pyogens infection?

A
  1. Penicillin-G
  2. Pencillin V / Amoxicillin
18
Q

What is the patomechanism of post-streptococcal rheumatic fever?

A

Type II hypersensitivity (cytotoxic antibodies)

19
Q

What is the patomechanism of post-streptococcal glomerulonephritis?

A

Type III hypersensitivity (immune complexes)

20
Q

Which Streptococcus special plays a major role in the meningitis of newborn babies?

A

Group B Streptococcus (S. agalactiae)

21
Q

What is (are) the major causative agent(s) for native valve infective endocarditis?

A

Viridans streptococci

22
Q

Mention 2 diseases that are frequently caused by enterococci

A
  1. Urinary tract infections
  2. Endocarditis
  3. Intrabdominal and pelvic infections
23
Q

What are the specific morphologic features of Streptococcus pneumoniae?

A
  1. Gram positive diplococcus
  2. Lancet shape
  3. Capsule
24
Q

Mention 3 diseases that are frequently caused by Streptococcus pneuomoniae

A
  1. Pneumonia
  2. Meninigitis
  3. Sinusitis
  4. Otitis media
  5. Sepsis
25
Q

What fast diagnostic procedure can be used in acute Neisseria gonorrhoeae infection?

A

Demonstration of bacterial (intracellular in PMNs) from urethral discharge by Gram or methylene blue stain; PCR amplification of bacterial DNA